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IDH-305

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Purity:99.13%

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COA HPLC HNMR

IDH-305

Catalog No. T15550Cas No. 1628805-46-8

IDH-305 is an orally available, mutation-selective, and brain-penetrant IDH1 inhibitor targeting the IDH1 (R132) mutation. IDH-305 is 200-fold more selective for mutant IDH1 isoforms than wild type with IC50s of 27 nM,28 nM and 6.14 nM for IDH1R132H, IDH1R132C and IDH1WT, respectively.

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Pack Size	Price	Availability
1 mg	$52	In Stock
5 mg	$128	In Stock
10 mg	$178	In Stock
25 mg	$369	In Stock
50 mg	$558	In Stock
1 mL x 10 mM (in DMSO)	$139	In Stock

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Product Introduction

Bioactivity

Description	IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor. IDH-305 shows greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50s: 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 µM (IDH1WT)).
In vitro	IDH-305 suppresses HCT116-IDH1R132H /- cells (IC50 of 24 nM)[1].
In vivo	P.o. administration of 30-300 mg/kg IDH-305 twice daily for 21 days suppresses 2-HG production and 2-HG-dependent tumor growth of an IDH1 mutant PDX melanoma model [1].

Chemical Properties

Molecular Weight	490.45
Formula	C23H22F4N6O2
Cas No.	1628805-46-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (203.90 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0389 mL	10.1947 mL	20.3894 mL	101.9472 mL
5 mM	0.4078 mL	2.0389 mL	4.0779 mL	20.3894 mL
10 mM	0.2039 mL	1.0195 mL	2.0389 mL	10.1947 mL
20 mM	0.1019 mL	0.5097 mL	1.0195 mL	5.0974 mL
50 mM	0.0408 mL	0.2039 mL	0.4078 mL	2.0389 mL
100 mM	0.0204 mL	0.1019 mL	0.2039 mL	1.0195 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc