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ALDH2 modulator 1

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Catalog No. T67832Cas No. 1629615-99-1

ALDH2 modulator 1 is a potent, orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.

ALDH2 modulator 1

ALDH2 modulator 1

🥰Excellent
Purity: 98.07%
Catalog No. T67832Cas No. 1629615-99-1
ALDH2 modulator 1 is a potent, orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.
Pack SizePriceAvailabilityQuantity
1 mg$58In Stock
5 mg$176In Stock
10 mg$278In Stock
25 mg$458In Stock
50 mg$642In Stock
100 mg$858In Stock
200 mg$1,160In Stock
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Purity:98.07%
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Product Introduction

Bioactivity
Description
ALDH2 modulator 1 is a potent, orally active modulator of acetaldehyde dehydrogenase-2 (ALDH2), which reduces blood alcohol levels in mice.
In vivo
'ALDH2 modulator 1 (compound 161) (10 mg/kg i.v.; 40, 60 mg/kg p.o.) reduces blood alcohol levels in mice administered 5 g/kg alcohol orally.[1]'
Chemical Properties
Molecular Weight364.8
FormulaC18H18ClFN2O3
Cas No.1629615-99-1
SmilesO(CC1CC1)C2=C(C(NCC3=CC(F)=C(OC)C=C3)=O)C(Cl)=CC=N2
Relative Density.1.316 g/cm3 (Predicted)
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 3.65 mg/mL (10 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7412 mL13.7061 mL27.4123 mL137.0614 mL
5 mM0.5482 mL2.7412 mL5.4825 mL27.4123 mL
10 mM0.2741 mL1.3706 mL2.7412 mL13.7061 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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