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BI-9627

BI-9627
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BI-9627

Catalog No. T14566Cas No. 1204329-34-9
BI-9627 is a selective and potent sodium hydrogen exchange isomer 1 (NHE1) inhibitor.BI-9627 partially reverses the effects of DMA with IC50 values of 6 and 31 nM in the intracellular pH recovery (pHi) and human platelet lysis assays.BI-9627 is often used as a negative control for BI-0054, which can be used for the study of ischemia-reperfusion injury in isolated hearts. BI-9627 is often used as a negative control for BI-0054 and can be used to study ischemia-reperfusion injury in isolated hearts.
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Pack SizePriceAvailabilityQuantity
2 mg$525 days
10 mg$1647-10 days
50 mg$5407-10 days
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Product Introduction

Bioactivity
Description
BI-9627 is a selective and potent sodium hydrogen exchange isomer 1 (NHE1) inhibitor.BI-9627 partially reverses the effects of DMA with IC50 values of 6 and 31 nM in the intracellular pH recovery (pHi) and human platelet lysis assays.BI-9627 is often used as a negative control for BI-0054, which can be used for the study of ischemia-reperfusion injury in isolated hearts. BI-9627 is often used as a negative control for BI-0054 and can be used to study ischemia-reperfusion injury in isolated hearts.
Chemical Properties
Molecular Weight356.34
FormulaC16H19F3N4O2
Cas No.1204329-34-9
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 80 mg/mL (224.50 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8063 mL14.0315 mL28.0631 mL140.3154 mL
5 mM0.5613 mL2.8063 mL5.6126 mL28.0631 mL
10 mM0.2806 mL1.4032 mL2.8063 mL14.0315 mL
20 mM0.1403 mL0.7016 mL1.4032 mL7.0158 mL
50 mM0.0561 mL0.2806 mL0.5613 mL2.8063 mL
100 mM0.0281 mL0.1403 mL0.2806 mL1.4032 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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