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BMS 195614

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Purity:97.7%

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COA HNMR HPLC

BMS 195614

Catalog No. T22192Cas No. 253310-42-8

BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.

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Pack Size	Price	Availability
1 mg	$181	In Stock
5 mg	$418	In Stock
10 mg	$619	In Stock
25 mg	$988	In Stock
50 mg	$1,330	In Stock
100 mg	$1,780	In Stock
500 mg	$3,580	In Stock

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Product Introduction

Bioactivity

Description	BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.
In vitro	BMS 195614 reversed the induction effect of selective RARα agonists, AM580, AM80 and BMS 194753 on differentiation of the acute promyelocytic leukemia cell lines, NB4 and HL60 [1]. Treatment with retinoic acid (RA) (1 uM) for 72 hrs significantly reduced T47D breast cancer cells migration. But RA in combination with BMS 195614 did not affect the cell movement [2]. In cells of a bovine stromal-vascular fraction from intramuscular fat, BMS 195614 significantly diminished the anti-adipogenic effect of ATRA [3].
In vivo	BMS 195614 displayed poor in vivo activity in mice when administered orally. Treatment with BMS 195614 at oral doses for 1 month showed no inhibition to spermatogenesis [4]. Oral administration of BMS 195614 did not suppress spermatogenesis in mice [5].
Alias	BMS614

Chemical Properties

Molecular Weight	448.51
Formula	C29H24N2O3
Cas No.	253310-42-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10.1 mg/mL (22.5 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2296 mL	11.1480 mL	22.2960 mL	111.4802 mL
5 mM	0.4459 mL	2.2296 mL	4.4592 mL	22.2960 mL
10 mM	0.2230 mL	1.1148 mL	2.2296 mL	11.1480 mL
20 mM	0.1115 mL	0.5574 mL	1.1148 mL	5.5740 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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