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BMS 195614
🥰Excellent
Catalog No. T22192Cas No. 253310-42-8
Alias BMS614
BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.
BMS 195614
🥰Excellent
Purity: 97.7%
Catalog No. T22192Alias BMS614Cas No. 253310-42-8
BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $181 | In Stock | |
| 5 mg | $418 | In Stock | |
| 10 mg | $619 | In Stock | |
| 25 mg | $988 | In Stock | |
| 50 mg | $1,330 | In Stock | |
| 100 mg | $1,780 | In Stock | |
| 500 mg | $3,580 | In Stock |
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Purity:97.7%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit. |
| In vitro | BMS 195614 reversed the induction effect of selective RARα agonists, AM580, AM80 and BMS 194753 on differentiation of the acute promyelocytic leukemia cell lines, NB4 and HL60 [1]. Treatment with retinoic acid (RA) (1 uM) for 72 hrs significantly reduced T47D breast cancer cells migration. But RA in combination with BMS 195614 did not affect the cell movement [2]. In cells of a bovine stromal-vascular fraction from intramuscular fat, BMS 195614 significantly diminished the anti-adipogenic effect of ATRA [3]. |
| In vivo | BMS 195614 displayed poor in vivo activity in mice when administered orally. Treatment with BMS 195614 at oral doses for 1 month showed no inhibition to spermatogenesis [4]. Oral administration of BMS 195614 did not suppress spermatogenesis in mice [5]. |
| Alias | BMS614 |
| Molecular Weight | 448.51 |
| Formula | C29H24N2O3 |
| Cas No. | 253310-42-8 |
| Smiles | CC1(CC=C(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)C4=CC5=CC=CC=C5N=C4)C |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10.1 mg/mL (22.52 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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