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BRD0539

Name: BRD0539
Brand: TargetMol
SKU: T22279
Price: 189 EUR
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22279Cas No. 1403838-79-8

BRD0539 is a cell-permeable spCas9 inhibitor that blocks the binding of spCas9 to DNA and inhibits Streptococcus pyogenes Cas9 (SpCas9).

BRD0539

🥰Excellent

Purity: 98.03%

Catalog No. T22279Cas No. 1403838-79-8

BRD0539 is a cell-permeable spCas9 inhibitor that blocks the binding of spCas9 to DNA and inhibits Streptococcus pyogenes Cas9 (SpCas9).

Pack Size	Price	Availability	Quantity
1 mg	189 €	In Stock

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Purity:98.03%

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COA LCMS

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	BRD0539 is a cell-permeable spCas9 inhibitor that blocks the binding of spCas9 to DNA and inhibits Streptococcus pyogenes Cas9 (SpCas9).
Targets&IC50	SpCas9:22 μM

Chemical Properties

Molecular Weight	452.54
Formula	C₂₅H₂₅FN₂O₃S
Cas No.	1403838-79-8
Smiles	[H][C@]12CCN([C@@]1([H])c1cc(ccc1N[C@H]2CO)-c1ccccc1F)S(=O)(=O)c1ccc(C)cc1
Relative Density.	1.295 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 80 mg/mL (176.60 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2097 mL	11.0487 mL	22.0975 mL	110.4875 mL
5 mM	0.4419 mL	2.2097 mL	4.4195 mL	22.0975 mL
10 mM	0.2210 mL	1.1049 mL	2.2097 mL	11.0487 mL
20 mM	0.1105 mL	0.5524 mL	1.1049 mL	5.5244 mL
50 mM	0.0442 mL	0.2210 mL	0.4419 mL	2.2097 mL
100 mM	0.0221 mL	0.1105 mL	0.2210 mL	1.1049 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc