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L755507
🥰Excellent
Catalog No. T6872Cas No. 159182-43-1
L755507 is an effective, selective agonist of β3-AR（IC50=35 nM）.
L755507
🥰Excellent
Purity: 99.88%
Catalog No. T6872Cas No. 159182-43-1
L755507 is an effective, selective agonist of β3-AR（IC50=35 nM）.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $45 | In Stock | |
| 5 mg | $109 | In Stock | |
| 10 mg | $176 | In Stock | |
| 25 mg | $313 | In Stock | |
| 50 mg | $468 | In Stock | |
| 100 mg | $673 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $142 | In Stock |
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Purity:99.88%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | L755507 is an effective, selective agonist of β3-AR（IC50=35 nM）. |
| Targets&IC50 | β3-adrenoceptor:35 nM |
| In vitro | L-755,507 displays an excellent activity profile as an extremely potent human β3 adrenergic receptor agonist (β3 EC50 0.43 nM), with >440-fold selectivity over β1 and β2 binding[1]. L755507 causes a robust concentration-dependent increase in cAMP accumulation in CHO-K1 cells expressing human β3-adrenoceptors(pEC50 values of 12.3)[4]. In a recent study employing a high-throughput screen to identify chemicals capable of modulating HR-mediated genome editing, L-755507 is identified that could enhance HR repair by up to ninefold[3]. |
| In vivo | Acute exposure of rhesus monkeys to L-755,507 elicits lipolysis and metabolic rate elevation, and that chronic exposure increases uncoupling protein 1 expression in rhesus brown adipose tissue[2]. |
| Molecular Weight | 584.73 |
| Formula | C30H40N4O6S |
| Cas No. | 159182-43-1 |
| Smiles | CCCCCCNC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccc(CCNC[C@H](O)COc2ccc(O)cc2)cc1 |
| Relative Density. | 1.274g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (68.41 mM), Sonication is recommended.  Ethanol: 58.5 mg/mL (100 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
Ethanol
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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