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Brofaromine

Catalog No. T10617Cas No. 63638-91-5

Brofaromine (CGP 11305A) is an MAO inhibitor (IC50: 0.2 μM for MAO-A).

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Pack Size	Price	Availability
2 mg	$118	5 days
5 mg	$196	5 days
25 mg	$626	6-8 weeks
50 mg	$814	6-8 weeks
100 mg	$1,240	6-8 weeks
1 mL x 10 mM (in DMSO)	$222	5 days

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Product Introduction

Bioactivity

Description	Brofaromine (CGP 11305A) is an MAO inhibitor (IC50: 0.2 μM for MAO-A).
In vitro	In order to assess whether the protective effect is related to the inhibition of the MAO-A or due to another mechanism, the effect of Brofaromine is determined on the activity of MAO-A in cultured cortical cells. The cultured cortical cells have significant MAO-A activity. Brofaromine inhibits the enzyme in a concentration-dependent manner (IC50: 0.19?μM). Hill coefficient is 0.96. The enzyme is almost completely inhibited at 10?μM. Brofaromine inhibits MAO-A activity of our cultured cortical cells in a concentration-dependent manner. The IC50 range of Brofaromine is 0.01?μM to 0.1?μM.
Alias	CGP 11305A

Chemical Properties

Molecular Weight	310.19
Formula	C14H16BrNO2
Cas No.	63638-91-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (805.96 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2238 mL	16.1192 mL	32.2383 mL	161.1915 mL
5 mM	0.6448 mL	3.2238 mL	6.4477 mL	32.2383 mL
10 mM	0.3224 mL	1.6119 mL	3.2238 mL	16.1192 mL
20 mM	0.1612 mL	0.8060 mL	1.6119 mL	8.0596 mL
50 mM	0.0645 mL	0.3224 mL	0.6448 mL	3.2238 mL
100 mM	0.0322 mL	0.1612 mL	0.3224 mL	1.6119 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc