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Calpain Inhibitor XII
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Catalog No. T21949Cas No. 181769-57-3
Alias Z-L-Nva-CONH-CH2-2-Py
Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a selective and potent inhibitor of calpain I, inhibits calpain II and cathepsin B. Calpain Inhibitor XII shows antiviral activity against coronavirus in cell culture.
Calpain Inhibitor XII
😃Good
Catalog No. T21949Alias Z-L-Nva-CONH-CH2-2-PyCas No. 181769-57-3
Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a selective and potent inhibitor of calpain I, inhibits calpain II and cathepsin B. Calpain Inhibitor XII shows antiviral activity against coronavirus in cell culture.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | 35 days | |
| 5 mg | $372 | 35 days | |
| 10 mg | $548 | 35 days | |
| 25 mg | $869 | 6-8weeks | |
| 50 mg | $1,170 | 6-8weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a selective and potent inhibitor of calpain I, inhibits calpain II and cathepsin B. Calpain Inhibitor XII shows antiviral activity against coronavirus in cell culture. |
| Targets&IC50 | SARS-CoV-2 (secondary VYR assay):0.78 µM (EC50), SARS-CoV-2 (primary CPE assay):0.49 µM (EC50) |
| In vitro | Four compounds boceprevir, calpain inhibitors II, Calpain Inhibitor XII, and GC-376 were chosen for the antiviral assay with infectious SARS-CoV-2. The most potent compound was Calpain Inhibitor XII, which showed an EC50 = 0.49 µM in the primary CPE assay and an EC50 = 0.78 µM in the secondary VYR assay. [1] |
| Alias | Z-L-Nva-CONH-CH2-2-Py |
| Molecular Weight | 482.57 |
| Formula | C26H34N4O5 |
| Cas No. | 181769-57-3 |
| Relative Density. | 1.167 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL(20.72 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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