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CD532

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Purity:99.49%

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COA HPLC HNMR

CD532

Catalog No. T50110Cas No. 1639009-81-6

CD532 is A highly potent Aurora A kinase inhibitor with an IC50 value of 45 nM. CD532 can block Aurora A kinase activity, drive MYCN degradation, and can directly interact with AURKA and induce global conformational transformation. CD532 can be used to study cancer.

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Pack Size	Price	Availability
1 mg	$33	In Stock
5 mg	$76	In Stock
10 mg	$122	In Stock
25 mg	$239	In Stock
50 mg	Inquiry	In Stock

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Product Introduction

Bioactivity

Description	CD532 is A highly potent Aurora A kinase inhibitor with an IC50 value of 45 nM. CD532 can block Aurora A kinase activity, drive MYCN degradation, and can directly interact with AURKA and induce global conformational transformation. CD532 can be used to study cancer.
In vitro	In MYCN-amplified neuroblastoma cell lines SK-N-BE(2) and Kelly, CD532 (1-10000 nM; 72 h) exhibits cytotoxicity with EC50s of 223.2 nM and 146.7 nM, respectively[1]. In SK-N-BE(2) cells, CD532 (0.1-1 μM; 24 h) causes a dose-dependent loss of MYCN protein[1]. Furthermore, CD532 (1 μM; 6 h) prevents S-phase entry in SK-N-BE(2) cells[1].
In vivo	In mice with subcutaneous sonic hedgehog (SHH)-subtype medulloblastoma, CD532 (25 mg/kg; i.p. twice weekly for 3 weeks) decreases the tumor volume and increases survival[1]. In MYCN-amplified neuroblastoma xenografts, CD532 (60 mg/kg; i.p. for 2 days) reduces the level of MYCN protein[1]. CD532 (20 mg/kg; i.p.) in mice exhibits a serum half-life of ~1.5 hours and an AUC0-24 of 27 μM•h[1].

Chemical Properties

Molecular Weight	522.52
Formula	C26H25F3N8O
Cas No.	1639009-81-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 200 mg/mL (382.76 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9138 mL	9.5690 mL	19.1380 mL	95.6901 mL
5 mM	0.3828 mL	1.9138 mL	3.8276 mL	19.1380 mL
10 mM	0.1914 mL	0.9569 mL	1.9138 mL	9.5690 mL
20 mM	0.0957 mL	0.4785 mL	0.9569 mL	4.7845 mL
50 mM	0.0383 mL	0.1914 mL	0.3828 mL	1.9138 mL
100 mM	0.0191 mL	0.0957 mL	0.1914 mL	0.9569 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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