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Cenerimod
🥰Excellent
Catalog No. T14924Cas No. 1262414-04-9
Alias ACT-334441
Cenerimod (ACT-334441) is an orally active, selective, and potent sphingosine 1-phosphate receptor (S1P1) agonist (EC50: 1 nM).Cenerimod inhibits multiple S1P isoforms and can be used to study murine experimental autoimmune encephalomyelitis (EAE) and murine scleroderma.
Cenerimod
🥰Excellent
Purity: 97.43%
Catalog No. T14924Alias ACT-334441Cas No. 1262414-04-9
Cenerimod (ACT-334441) is an orally active, selective, and potent sphingosine 1-phosphate receptor (S1P1) agonist (EC50: 1 nM).Cenerimod inhibits multiple S1P isoforms and can be used to study murine experimental autoimmune encephalomyelitis (EAE) and murine scleroderma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $35 | In Stock | |
| 5 mg | $56 | In Stock | |
| 10 mg | $95 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $62 | In Stock |
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Purity:97.43%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Cenerimod (ACT-334441) is an orally active, selective, and potent sphingosine 1-phosphate receptor (S1P1) agonist (EC50: 1 nM).Cenerimod inhibits multiple S1P isoforms and can be used to study murine experimental autoimmune encephalomyelitis (EAE) and murine scleroderma. |
| Targets&IC50 | S1PR4:2134 nM (EC50), S1PR1:1 nM (EC50), S1PR5:228 nM (EC50), S1PR5:36 nM (EC50) |
| In vitro | Cultured fibroblasts were pretreated with a vehicle or Cenerimod (5 μmol/L), followed by incubation with TGF-β2 (10 ng/mL) for 24 hours. The results indicated that Cenerimod inhibited collagen production in fibroblasts[1]. |
| In vivo | In male Wistar rats weighing 294-510 g, Cenerimod (0.1, 0.3, 1, 3, and 10 mg/kg; single oral dose) effectively and reversibly reduced blood lymphocyte counts[1]. |
| Alias | ACT-334441 |
| Molecular Weight | 453.53 |
| Formula | C25H31N3O5 |
| Cas No. | 1262414-04-9 |
| Smiles | CCc1cc(cc(C)c1OC[C@@H](O)CO)-c1noc(n1)-c1cc(OC)nc(c1)C1CCCC1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (176.39 mM), Sonification is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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