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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $56 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $178 | In Stock | |
50 mg | $296 | In Stock | |
100 mg | $515 | In Stock | |
200 mg | $739 | In Stock | |
500 mg | $1,150 | In Stock |
Description | CH-223191 is a potent and specific antagonist for the aryl hydrocarbon receptor (AhR). |
Targets&IC50 | AhR:30 nM |
In vitro | Daily oral administration of 10 mg/kg CH-223191 effectively prevents cytochrome P450 induction, wasting syndrome, and hepatotoxicity in mice caused by exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. |
In vivo | CH-223191 downregulates the TGF-β/Smad pathway in human glioblastoma cells, consequently reducing clonogenic survival and invasiveness. In neuron cells derived from human SK-N-SH, it counteracts the suppression of neuronal acetylcholinesterase expression induced by TCDD. Moreover, CH-223191 blocks the nuclear translocation and DNA binding of AhR mediated by TCDD and also inhibits the activation of cytochrome P450 enzyme activity induced by TCDD. Additionally, CH-223191 enhances the expression of ICAM-1 in endothelial cells and prevents the nuclear translocation of RelB. |
Alias | CH 223191 |
Molecular Weight | 333.39 |
Formula | C19H19N5O |
Cas No. | 301326-22-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 3.3 mg/mL (10 mM) DMSO: 60 mg/mL (179.97 mM) ![]() | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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