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CH-223191

🥰Excellent
Catalog No. T2448Cas No. 301326-22-7
Alias CH 223191

CH-223191 is a potent and specific antagonist for the aryl hydrocarbon receptor (AhR).

CH-223191

CH-223191

🥰Excellent
Purity: 99.71%
Catalog No. T2448Alias CH 223191Cas No. 301326-22-7
CH-223191 is a potent and specific antagonist for the aryl hydrocarbon receptor (AhR).
Pack SizePriceAvailabilityQuantity
5 mg$56 In Stock
10 mg$98 In Stock
25 mg$178 In Stock
50 mg$296 In Stock
100 mg$515 In Stock
200 mg$739 In Stock
500 mg$1,150 In Stock
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Purity:99.71%
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Product Introduction

Bioactivity
Description
CH-223191 is a potent and specific antagonist for the aryl hydrocarbon receptor (AhR).
Targets&IC50
AhR:30 nM
In vitro
CH-223191 downregulates the TGF-β/Smad pathway in human glioblastoma cells and reduces clonogenic survival and invasiveness. In SK-N-SH human-derived neuronal cells, CH-223191 counteracts TCDD-induced inhibition of neuronal acetylcholinesterase expression. CH-223191 blocks TCDD-mediated nuclear translocation and AhR DNA binding, while also inhibiting TCDD-induced cytochrome P450 enzyme activity. Additionally, CH-223191 enhances ICAM-1 expression in endothelial cells and prevents RelB nuclear translocation.
In vivo
Oral administration of CH-223191 at 10 mg/kg per day effectively prevents dioxin (TCDD)-induced cytochrome P450-mediated wasting syndrome and hepatotoxicity in mice.
AliasCH 223191
Chemical Properties
Molecular Weight333.39
FormulaC19H19N5O
Cas No.301326-22-7
SmilesCc1ccccc1\N=N\c1ccc(NC(=O)c2ccnn2C)c(C)c1
Relative Density.1.20 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 3.3 mg/mL (9.9 mM), Sonication is recommended.
DMSO: 60 mg/mL (179.97 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.9995 mL14.9975 mL29.9949 mL149.9745 mL
5 mM0.5999 mL2.9995 mL5.9990 mL29.9949 mL
DMSO
1mg5mg10mg50mg
10 mM0.2999 mL1.4997 mL2.9995 mL14.9975 mL
20 mM0.1500 mL0.7499 mL1.4997 mL7.4987 mL
50 mM0.0600 mL0.2999 mL0.5999 mL2.9995 mL
100 mM0.0300 mL0.1500 mL0.2999 mL1.4997 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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