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CH-223191
🥰Excellent
Catalog No. T2448Cas No. 301326-22-7
Alias CH 223191
CH-223191 is a potent and specific antagonist for the aryl hydrocarbon receptor (AhR).
CH-223191
🥰Excellent
Purity: 99.58%
Catalog No. T2448Alias CH 223191Cas No. 301326-22-7
CH-223191 is a potent and specific antagonist for the aryl hydrocarbon receptor (AhR).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $56 | In Stock | |
| 10 mg | $98 | In Stock | |
| 25 mg | $178 | In Stock | |
| 50 mg | $296 | In Stock | |
| 100 mg | $515 | In Stock | |
| 200 mg | $739 | In Stock | |
| 500 mg | $1,150 | In Stock |
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Purity:99.58%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CH-223191 is a potent and specific antagonist for the aryl hydrocarbon receptor (AhR). |
| Targets&IC50 | AhR:30 nM |
| In vitro | Daily oral administration of 10 mg/kg CH-223191 effectively prevents cytochrome P450 induction, wasting syndrome, and hepatotoxicity in mice caused by exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. |
| In vivo | CH-223191 downregulates the TGF-β/Smad pathway in human glioblastoma cells, consequently reducing clonogenic survival and invasiveness. In neuron cells derived from human SK-N-SH, it counteracts the suppression of neuronal acetylcholinesterase expression induced by TCDD. Moreover, CH-223191 blocks the nuclear translocation and DNA binding of AhR mediated by TCDD and also inhibits the activation of cytochrome P450 enzyme activity induced by TCDD. Additionally, CH-223191 enhances the expression of ICAM-1 in endothelial cells and prevents the nuclear translocation of RelB. |
| Alias | CH 223191 |
| Molecular Weight | 333.39 |
| Formula | C19H19N5O |
| Cas No. | 301326-22-7 |
| Smiles | Cc1ccccc1\N=N\c1ccc(NC(=O)c2ccnn2C)c(C)c1 |
| Relative Density. | 1.20 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 3.3 mg/mL (10 mM) DMSO: 60 mg/mL (179.97 mM)  | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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