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CH-223191 is a potent and specific antagonist for the aryl hydrocarbon receptor (AhR).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $56 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $178 | In Stock | |
50 mg | $296 | In Stock | |
100 mg | $515 | In Stock | |
200 mg | $739 | In Stock | |
500 mg | $1,150 | In Stock |
Description | CH-223191 is a potent and specific antagonist for the aryl hydrocarbon receptor (AhR). |
Targets&IC50 | AhR:30 nM |
In vitro | CH-223191 downregulates the TGF-β/Smad pathway in human glioblastoma cells and reduces clonogenic survival and invasiveness. In SK-N-SH human-derived neuronal cells, CH-223191 counteracts TCDD-induced inhibition of neuronal acetylcholinesterase expression. CH-223191 blocks TCDD-mediated nuclear translocation and AhR DNA binding, while also inhibiting TCDD-induced cytochrome P450 enzyme activity. Additionally, CH-223191 enhances ICAM-1 expression in endothelial cells and prevents RelB nuclear translocation. |
In vivo | Oral administration of CH-223191 at 10 mg/kg per day effectively prevents dioxin (TCDD)-induced cytochrome P450-mediated wasting syndrome and hepatotoxicity in mice. |
Alias | CH 223191 |
Molecular Weight | 333.39 |
Formula | C19H19N5O |
Cas No. | 301326-22-7 |
Smiles | Cc1ccccc1\N=N\c1ccc(NC(=O)c2ccnn2C)c(C)c1 |
Relative Density. | 1.20 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 3.3 mg/mL (9.9 mM), Sonication is recommended. DMSO: 60 mg/mL (179.97 mM), Sonication is recommended. ![]() | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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