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Chymase-IN-1

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Purity:99.21%

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COA HNMR HPLC

Chymase-IN-1

Catalog No. T10811Cas No. 862090-74-2

Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).

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Pack Size	Price	Availability
1 mg	$157	In Stock
5 mg	$388	In Stock
10 mg	$553	In Stock
25 mg	$828	In Stock
50 mg	$1,110	In Stock
100 mg	$1,490	In Stock
500 mg	$2,950	In Stock
1 mL x 10 mM (in DMSO)	$426	In Stock

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Product Introduction

Bioactivity

Description	Chymase-IN-1 is a selective, orally active inhibitor of human mast cell chymase (IC50: 29 nM).
In vitro	Chymase-IN-1 (compound 5f) has a chymase Ki value of 36 nM and a Cat G Ki value of 9500 nM[1].
In vivo	Chymase-IN-1 shows low oral bioavailability in rats (F=3%; oral t1/2=1.8 h)[1].

Chemical Properties

Molecular Weight	431.83
Formula	C20H15ClNO4PS
Cas No.	862090-74-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (115.79 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3157 mL	11.5786 mL	23.1573 mL	115.7863 mL
5 mM	0.4631 mL	2.3157 mL	4.6315 mL	23.1573 mL
10 mM	0.2316 mL	1.1579 mL	2.3157 mL	11.5786 mL
20 mM	0.1158 mL	0.5789 mL	1.1579 mL	5.7893 mL
50 mM	0.0463 mL	0.2316 mL	0.4631 mL	2.3157 mL
100 mM	0.0232 mL	0.1158 mL	0.2316 mL	1.1579 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc