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Corynoxine B
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Catalog No. TQ0258Cas No. 17391-18-3
Corynoxine B (Cory B), a natural alkaloid isolated from Uncaria rhynchophylla (Miq. ), is an autophagy inducer that enhances the activity of Beclin 1/VPS34 complex and increases autophagy by facilitating the interaction between Beclin 1 and HMGB1/2, which may ameliorate Alzheimer's disease. NVP-BAG956 (NVP-BAG956)
Corynoxine B
😃Good
Purity: 99.72%
Catalog No. TQ0258Cas No. 17391-18-3
Corynoxine B (Cory B), a natural alkaloid isolated from Uncaria rhynchophylla (Miq. ), is an autophagy inducer that enhances the activity of Beclin 1/VPS34 complex and increases autophagy by facilitating the interaction between Beclin 1 and HMGB1/2, which may ameliorate Alzheimer's disease. NVP-BAG956 (NVP-BAG956)
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $93 | 7-10 days | |
| 5 mg | $228 | 7-10 days | |
| 1 mL x 10 mM (in DMSO) | $253 | 7-10 days |
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Purity:99.72%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Corynoxine B (Cory B), a natural alkaloid isolated from Uncaria rhynchophylla (Miq. ), is an autophagy inducer that enhances the activity of Beclin 1/VPS34 complex and increases autophagy by facilitating the interaction between Beclin 1 and HMGB1/2, which may ameliorate Alzheimer's disease. NVP-BAG956 (NVP-BAG956) |
| In vitro | 25-100 μM Corynoxine B, treated for 2 h, ameliorated autophagy dysregulation and neurotoxicity in Mn-induced SH-SY5Y human neuroblastoma cells. [1] In PC12 cells, Corynoxine B upregulated BECN1 protein expression and restored autophagy inhibition induced by SNCA/α-synuclein (α-syn) overexpression. [2] |
| In vivo | In a mouse model of Parkinson's disease, intraperitoneal injection of 5-20 mg/kg Corynoxine B promotes autophagic clearance of α-synuclein (α-syn) by targeting HMGB1/2. [3] |
| Molecular Weight | 384.47 |
| Formula | C22H28N2O4 |
| Cas No. | 17391-18-3 |
| Smiles | O=C1[C@@]2([C@]3(N(CC2)C[C@@H](CC)[C@@H](\C(\C(OC)=O)=C/OC)C3)[H])C=4C(N1)=CC=CC4 |
| Relative Density. | 1.23 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (208.08 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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