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Damnacanthal
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Catalog No. TN1549Cas No. 477-84-9
Alias Damnacantal
Damnacanthal is a natural anthraquinone compound with potential anticancer, anti-inflammatory, antioxidant, anti-malarial, and antiviral effects.Damnacanthal inhibits a variety of protein kinases such as LIMK1 (IC50=0.8 μM), LIMK2 (IC50=1.5 μM), and Lck (IC50=17 nM), and inhibits the growth of human hepatocellular carcinoma (SKHep-1) and human breast cancer (MCF-7) cells.
Damnacanthal
😃Good
Catalog No. TN1549Alias DamnacantalCas No. 477-84-9
Damnacanthal is a natural anthraquinone compound with potential anticancer, anti-inflammatory, antioxidant, anti-malarial, and antiviral effects.Damnacanthal inhibits a variety of protein kinases such as LIMK1 (IC50=0.8 μM), LIMK2 (IC50=1.5 μM), and Lck (IC50=17 nM), and inhibits the growth of human hepatocellular carcinoma (SKHep-1) and human breast cancer (MCF-7) cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $800 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Damnacanthal is a natural anthraquinone compound with potential anticancer, anti-inflammatory, antioxidant, anti-malarial, and antiviral effects.Damnacanthal inhibits a variety of protein kinases such as LIMK1 (IC50=0.8 μM), LIMK2 (IC50=1.5 μM), and Lck (IC50=17 nM), and inhibits the growth of human hepatocellular carcinoma (SKHep-1) and human breast cancer (MCF-7) cells. |
| Targets&IC50 | p56lck autophosphorylation:46 nM (IC50), Phosphorylation of exogenous substrates by p56lck:220 nM (IC50) |
| In vitro | Methods: Damnacanthal (100nM, 1, 10, 100μM, 1, 2, 4 days) was used to treat HCT-116 and SW480 cells to study its antiproliferative effects on human colorectal cancer cell types. Results: Treatment of HCT-116 cells with Damnacanthal resulted in a significant decrease in cell proliferation at 1 μM (P < 0.05), 10 μM (P < 0.01), and 100 μM (P < 0.01) after 4 days of treatment; SW480 cells also showed a significant decrease in cell proliferation at 10 μM (P < 0.05) and 100 μM (P < 0.001) after 4 days of treatment with Damnacanthal; Damnacanthal had a cytotoxic effect on colorectal cancer cells in both p53 wild-type (HCT-116) and p53 mutant (SW480) cells. Methods: HCT-116 cells were treated with Damnacanthal (1, 10, 50 μM) to determine its possible inhibitory effects on cell cycle progression and apoptosis, and caspase 3/7 activity was measured. Results: Treatment of HCT-116 cells with Damnacanthal (50 μM) resulted in a significant enrichment of cells in the S/G1 and G2/G1 phases. Treatment of HCT-116 cells with Damnacanthal (10 μM) significantly increased caspase 3/7 activity. [2] |
| In vivo | Damnacanthal (10-100 mg/kg, oral, 10-300 minutes) treatment of mice showed a dose-dependent and significant antinociceptive effect in the formalin test, and mice treated with Damnacanthal (100 mg/kg) significantly inhibited histamine-induced paw edema[3]. |
| Alias | Damnacantal |
| Molecular Weight | 282.25 |
| Formula | C16H10O5 |
| Cas No. | 477-84-9 |
| Smiles | O=CC1=C(O)C=C2C(=O)C=3C=CC=CC3C(=O)C2=C1OC |
| Relative Density. | 1.461g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 2 mg/mL (7.09 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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