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Dihomo-γ-linolenic acid

Catalog No. TQ0262Cas No. 1783-84-2
Alias Ro 12-1989, Diroleuton, all-cis-8,11,14-Eicosatrienoic acid

Dihomo-γ-linolenic acid (DGLA) is a fatty acid widely found in plants with antitumor and antiproliferative effects, inhibits the growth of xenograft tumor cells, and can be used in the study of inflammation-related diseases such as rheumatoid arthritis, atherosclerosis, and atopic dermatitis.

Dihomo-γ-linolenic acid

Dihomo-γ-linolenic acid

Catalog No. TQ0262Alias Ro 12-1989, Diroleuton, all-cis-8,11,14-Eicosatrienoic acidCas No. 1783-84-2
Dihomo-γ-linolenic acid (DGLA) is a fatty acid widely found in plants with antitumor and antiproliferative effects, inhibits the growth of xenograft tumor cells, and can be used in the study of inflammation-related diseases such as rheumatoid arthritis, atherosclerosis, and atopic dermatitis.
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1 mg$308-10 weeks
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Product Introduction

Bioactivity
Description
Dihomo-γ-linolenic acid (DGLA) is a fatty acid widely found in plants with antitumor and antiproliferative effects, inhibits the growth of xenograft tumor cells, and can be used in the study of inflammation-related diseases such as rheumatoid arthritis, atherosclerosis, and atopic dermatitis.
In vitro
In THP-1 macrophages, Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ-induced phosphorylation of STAT1 at serine 727[2].
In vivo
In 48 four-week-old female nude mice, administration of 8 mg per mouse via oral gavage twice a week for 35 days suppressed the metastatic potential of D5D-KD tumors[3].
AliasRo 12-1989, Diroleuton, all-cis-8,11,14-Eicosatrienoic acid
Chemical Properties
Molecular Weight306.48
FormulaC20H34O2
Cas No.1783-84-2
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (261.03 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.2629 mL16.3143 mL32.6286 mL163.1428 mL
5 mM0.6526 mL3.2629 mL6.5257 mL32.6286 mL
10 mM0.3263 mL1.6314 mL3.2629 mL16.3143 mL
20 mM0.1631 mL0.8157 mL1.6314 mL8.1571 mL
50 mM0.0653 mL0.3263 mL0.6526 mL3.2629 mL
100 mM0.0326 mL0.1631 mL0.3263 mL1.6314 mL

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