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Dihomo-γ-linolenic acid
🥰Excellent
Catalog No. TQ0262Cas No. 1783-84-2
Alias Ro 12-1989, Diroleuton, all-cis-8,11,14-Eicosatrienoic acid
Dihomo-γ-linolenic acid (DGLA) is a fatty acid widely found in plants with antitumor and antiproliferative effects, inhibits the growth of xenograft tumor cells, and can be used in the study of inflammation-related diseases such as rheumatoid arthritis, atherosclerosis, and atopic dermatitis.
Dihomo-γ-linolenic acid
🥰Excellent
Catalog No. TQ0262Alias Ro 12-1989, Diroleuton, all-cis-8,11,14-Eicosatrienoic acidCas No. 1783-84-2
Dihomo-γ-linolenic acid (DGLA) is a fatty acid widely found in plants with antitumor and antiproliferative effects, inhibits the growth of xenograft tumor cells, and can be used in the study of inflammation-related diseases such as rheumatoid arthritis, atherosclerosis, and atopic dermatitis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $50 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Dihomo-γ-linolenic acid (DGLA) is a fatty acid widely found in plants with antitumor and antiproliferative effects, inhibits the growth of xenograft tumor cells, and can be used in the study of inflammation-related diseases such as rheumatoid arthritis, atherosclerosis, and atopic dermatitis. |
| In vitro | In THP-1 macrophages, Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ-induced phosphorylation of STAT1 at serine 727[2]. |
| In vivo | In 48 four-week-old female nude mice, administration of 8 mg per mouse via oral gavage twice a week for 35 days suppressed the metastatic potential of D5D-KD tumors[3]. |
| Alias | Ro 12-1989, Diroleuton, all-cis-8,11,14-Eicosatrienoic acid |
| Molecular Weight | 306.48 |
| Formula | C20H34O2 |
| Cas No. | 1783-84-2 |
| Smiles | CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O |
| Relative Density. | 0.917g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (261.03 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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