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Dopropidil

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Catalog No. T11080Cas No. 79700-61-1

Dopropidil is a new anti-angina pectoris calcium regulator, which has intracellular calcium antagonist activity and anti-ischemic effects in various predicted animal models.

Dopropidil

Dopropidil

😃Good
Catalog No. T11080Cas No. 79700-61-1
Dopropidil is a new anti-angina pectoris calcium regulator, which has intracellular calcium antagonist activity and anti-ischemic effects in various predicted animal models.
Pack SizePriceAvailabilityQuantity
25 mg$1,5206-8 weeks
50 mg$1,9806-8 weeks
100 mg$2,5006-8 weeks
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Product Introduction

Bioactivity
Description
Dopropidil is a new anti-angina pectoris calcium regulator, which has intracellular calcium antagonist activity and anti-ischemic effects in various predicted animal models.
In vitro
In the calcium-free medium (IC50 = 30.0 uM), dopredil can inhibit caffeine-induced contraction of rabbit renal arteries. Dopredil inhibits norepinephrine (NE)-induced responses with IC50 of 2.7 and 29.8 uM, respectively. At 3 μM and 10 μM, dopredil significantly reduced the maximum increase in diastolic pressure caused by veratrine (IC50 = 2.8 μM).
In vivo
Dopamine (1 and 2.5 mg/kg) dose-dependently reduced electrical (ST segment elevation), biochemical (lactate production and potassium release) and mechanical (myocardial segment contractility loss) disturbances caused by ischemia in anesthetized dogs. Intraduodenal administration of dopredil (50 mg/kg) can significantly reduce tachycardia caused by isoproterenol. This effect is evident between 15 and 120 minutes after application of the compound, indicating rapid absorption and long duration of action. In awake dogs, doprodil (12-14 mg/kg p.o.) can reduce the resting heart rate by about 10 beats/minute.
Chemical Properties
Molecular Weight321.5
FormulaC20H35NO2
Cas No.79700-61-1
Relative Density.0.99g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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