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Signaling PathwaysOthersOthersELOVL1-IN-1
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ELOVL1-IN-1

ELOVL1-IN-1
ELOVL1-IN-1 (1-(2-Fluorophenyl)-N-(1-(2-fluoropyridin-4-YL)-1H-pyrazol-3-YL)cyclopropane-1-carboxamide) is an ELOVL1 inhibitor. ELOVL1-IN-1 can reduce the levels of very long chain fatty acids. ELOVL1-IN-1 can be used in the study of adrenoleukodystrophy (ALD).
Catalog No. T9578Cas No. 2227482-41-7
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Purity:98.55%
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COA HNMR HPLC

ELOVL1-IN-1

Catalog No. T9578Cas No. 2227482-41-7
ELOVL1-IN-1 (1-(2-Fluorophenyl)-N-(1-(2-fluoropyridin-4-YL)-1H-pyrazol-3-YL)cyclopropane-1-carboxamide) is an ELOVL1 inhibitor. ELOVL1-IN-1 can reduce the levels of very long chain fatty acids. ELOVL1-IN-1 can be used in the study of adrenoleukodystrophy (ALD).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$136In Stock
5 mg$338In Stock
10 mg$497In Stock
25 mg$890In Stock
50 mg$1,270In Stock
100 mg$1,650In Stock
1 mL x 10 mM (in DMSO)$386In Stock
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Product Introduction

Bioactivity
Description
ELOVL1-IN-1 (1-(2-Fluorophenyl)-N-(1-(2-fluoropyridin-4-YL)-1H-pyrazol-3-YL)cyclopropane-1-carboxamide) is an ELOVL1 inhibitor. ELOVL1-IN-1 can reduce the levels of very long chain fatty acids. ELOVL1-IN-1 can be used in the study of adrenoleukodystrophy (ALD).
In vitro
Administration of 1 nM-10 μM ELOVL1-IN-1 for 48 h reduces the level of VLCFA, lysophosphatidylcholine (LPC) in adrenoleukodystrophy (ALD) patient fibroblasts and healthy human fibroblasts, ALD patient B‐lymphocytes, and human microglia[1].
In vivo
Oral dministration of ELOVL1-IN-1 reduces of a VLCFA level, specifically C26:0 LPC level in blood of ABCD1 knockout mice (0.5-64 mg/kg; 28 days), wild‐type (WT) rats (30-300 mg/kg; 7 days), and cynomolgous monkeys (30 mg/kg; 7 days)[1].
Alias1-(2-Fluorophenyl)-N-(1-(2-fluoropyridin-4-YL)-1H-pyrazol-3-YL)cyclopropane-1-carboxamide
Chemical Properties
Molecular Weight340.33
FormulaC18H14F2N4O
Cas No.2227482-41-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (146.92 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9383 mL14.6916 mL29.3832 mL146.9162 mL
5 mM0.5877 mL2.9383 mL5.8766 mL29.3832 mL
10 mM0.2938 mL1.4692 mL2.9383 mL14.6916 mL
20 mM0.1469 mL0.7346 mL1.4692 mL7.3458 mL
50 mM0.0588 mL0.2938 mL0.5877 mL2.9383 mL
100 mM0.0294 mL0.1469 mL0.2938 mL1.4692 mL

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Keywords

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