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ELOVL1-IN-1

🥰Excellent
Catalog No. T9578Cas No. 2227482-41-7
Alias 1-(2-Fluorophenyl)-N-(1-(2-fluoropyridin-4-YL)-1H-pyrazol-3-YL)cyclopropane-1-carboxamide

ELOVL1-IN-1 (1-(2-Fluorophenyl)-N-(1-(2-fluoropyridin-4-YL)-1H-pyrazol-3-YL)cyclopropane-1-carboxamide) is an ELOVL1 inhibitor. ELOVL1-IN-1 can reduce the levels of very long chain fatty acids. ELOVL1-IN-1 can be used in the study of adrenoleukodystrophy (ALD).

ELOVL1-IN-1

ELOVL1-IN-1

🥰Excellent
Purity: 98.55%
Catalog No. T9578Alias 1-(2-Fluorophenyl)-N-(1-(2-fluoropyridin-4-YL)-1H-pyrazol-3-YL)cyclopropane-1-carboxamideCas No. 2227482-41-7
ELOVL1-IN-1 (1-(2-Fluorophenyl)-N-(1-(2-fluoropyridin-4-YL)-1H-pyrazol-3-YL)cyclopropane-1-carboxamide) is an ELOVL1 inhibitor. ELOVL1-IN-1 can reduce the levels of very long chain fatty acids. ELOVL1-IN-1 can be used in the study of adrenoleukodystrophy (ALD).
Pack SizePriceAvailabilityQuantity
1 mg$136In Stock
5 mg$338In Stock
10 mg$497In Stock
25 mg$890In Stock
50 mg$1,270In Stock
100 mg$1,650In Stock
1 mL x 10 mM (in DMSO)$386In Stock
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Purity:98.55%
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Product Introduction

Bioactivity
Description
ELOVL1-IN-1 (1-(2-Fluorophenyl)-N-(1-(2-fluoropyridin-4-YL)-1H-pyrazol-3-YL)cyclopropane-1-carboxamide) is an ELOVL1 inhibitor. ELOVL1-IN-1 can reduce the levels of very long chain fatty acids. ELOVL1-IN-1 can be used in the study of adrenoleukodystrophy (ALD).
In vitro
Administration of 1 nM-10 μM ELOVL1-IN-1 for 48 h reduces the level of VLCFA, lysophosphatidylcholine (LPC) in adrenoleukodystrophy (ALD) patient fibroblasts and healthy human fibroblasts, ALD patient B‐lymphocytes, and human microglia[1].
In vivo
Oral dministration of ELOVL1-IN-1 reduces of a VLCFA level, specifically C26:0 LPC level in blood of ABCD1 knockout mice (0.5-64 mg/kg; 28 days), wild‐type (WT) rats (30-300 mg/kg; 7 days), and cynomolgous monkeys (30 mg/kg; 7 days)[1].
Alias1-(2-Fluorophenyl)-N-(1-(2-fluoropyridin-4-YL)-1H-pyrazol-3-YL)cyclopropane-1-carboxamide
Chemical Properties
Molecular Weight340.33
FormulaC18H14F2N4O
Cas No.2227482-41-7
SmilesFc1cc(ccn1)-n1ccc(NC(=O)C2(CC2)c2ccccc2F)n1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (146.92 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9383 mL14.6916 mL29.3832 mL146.9162 mL
5 mM0.5877 mL2.9383 mL5.8766 mL29.3832 mL
10 mM0.2938 mL1.4692 mL2.9383 mL14.6916 mL
20 mM0.1469 mL0.7346 mL1.4692 mL7.3458 mL
50 mM0.0588 mL0.2938 mL0.5877 mL2.9383 mL
100 mM0.0294 mL0.1469 mL0.2938 mL1.4692 mL

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Keywords

longInhibitorinhibitfattyELOVL1-IN-1ELOVL-1-IN-1ELOVL1IN1ELOVL1 IN 1chainALDadrenoleukodystrophyacid
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