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ent-Ezetimibe

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Purity:98.30%

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COA HNMR HPLC

ent-Ezetimibe

Catalog No. T11205Cas No. 1376614-99-1

Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.ent-Ezetimibe (ent-SCH 58235) (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor.

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Pack Size	Price	Availability
1 mg	$178	In Stock
5 mg	$380	In Stock
10 mg	$563	In Stock
25 mg	$887	In Stock
50 mg	$1,230	In Stock
100 mg	$1,670	In Stock
1 mL x 10 mM (in DMSO)	$430	In Stock

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Product Introduction

Bioactivity

Description	Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.ent-Ezetimibe (ent-SCH 58235) (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor.
Alias	ent-SCH 58235

Chemical Properties

Molecular Weight	409.43
Formula	C24H21F2NO3
Cas No.	1376614-99-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (146.55 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4424 mL	12.2121 mL	24.4242 mL	122.1210 mL
5 mM	0.4885 mL	2.4424 mL	4.8848 mL	24.4242 mL
10 mM	0.2442 mL	1.2212 mL	2.4424 mL	12.2121 mL
20 mM	0.1221 mL	0.6106 mL	1.2212 mL	6.1060 mL
50 mM	0.0488 mL	0.2442 mL	0.4885 mL	2.4424 mL
100 mM	0.0244 mL	0.1221 mL	0.2442 mL	1.2212 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

entEzetimibeInhibitorent-SCH58235ent EzetimibeRRS-enantiomerent-SCH-58235Drug Metaboliteent-Ezetimibeinhibit