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Enterolactone
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Catalog No. T41314Cas No. 78473-71-9
Alias trans-α,β-Bis(3-hydroxybenzyl)butyrolactone
Enterolactone (trans-α,β-Bis(3-hydroxybenzyl)butyrolactone) is a bioactive phenolic metabolite with estrogenic properties and anti-breast cancer activity. It strongly inhibits cancer cell proliferation and migration by upregulating THBS1, synergistically suppressing epithelial ovarian cancer.
Enterolactone
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Catalog No. T41314Alias trans-α,β-Bis(3-hydroxybenzyl)butyrolactoneCas No. 78473-71-9
Enterolactone (trans-α,β-Bis(3-hydroxybenzyl)butyrolactone) is a bioactive phenolic metabolite with estrogenic properties and anti-breast cancer activity. It strongly inhibits cancer cell proliferation and migration by upregulating THBS1, synergistically suppressing epithelial ovarian cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | $78 | 35 days | |
| 1 mg | $120 | In Stock | |
| 5 mg | $383 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Enterolactone (trans-α,β-Bis(3-hydroxybenzyl)butyrolactone) is a bioactive phenolic metabolite with estrogenic properties and anti-breast cancer activity. It strongly inhibits cancer cell proliferation and migration by upregulating THBS1, synergistically suppressing epithelial ovarian cancer. |
| In vitro | Enterolactone (150 μM, 48h) combined with Trabe significantly inhibited the proliferation and migration of human EOC cells. [1] Enterolactone (25-75 μM,48h) blocks the growth of MDA-MB-231 breast cancer cells in the "S" phase. Enterolactone (25-75 μM,15 h) triggers apoptosis of MDA-MB-231 breast cancer cells through caspase-3 activation. [2] |
| In vivo | The expression of THBS1 gene in Enterolactone (l mg/kg, intraperitoneal injection) treatment group was significantly up-regulated. [1] |
| Alias | trans-α,β-Bis(3-hydroxybenzyl)butyrolactone |
| Molecular Weight | 298.33 |
| Formula | C18H18O4 |
| Cas No. | 78473-71-9 |
| Smiles | C([C@H]1[C@H](CC2=CC(O)=CC=C2)C(=O)OC1)C3=CC(O)=CC=C3 |
| Relative Density. | 1.298 g/cm3 at 20℃ |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 20.00 mg/mL (67.04 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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