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ERAP1-IN-1

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Purity:98.60%

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COA HNMR HPLC

ERAP1-IN-1

Catalog No. T11221Cas No. 865273-97-8

ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 allosterically activates ERAP1’s hydrolysis of fluorogenic and chromogenic amino acid substrates but competitively inhibits its activity toward a nonamer peptide representative of physiological substrates.

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Pack Size	Price	Availability
1 mg	$135	In Stock
5 mg	$289	In Stock
10 mg	$478	In Stock
25 mg	$789	In Stock
50 mg	$1,080	In Stock
100 mg	$1,480	In Stock
500 mg	$2,970	In Stock
1 mL x 10 mM (in DMSO)	$289	In Stock

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Product Introduction

Bioactivity

Description	ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 allosterically activates ERAP1’s hydrolysis of fluorogenic and chromogenic amino acid substrates but competitively inhibits its activity toward a nonamer peptide representative of physiological substrates.
In vitro	ERAP1-IN-1 (50 μM) exhibits specific inhibition of ERAP1 in the cellular context. ERAP1-IN-1 allosterically activates ERAP1’s hydrolysis of fluorogenic and chromogenic amino acid substrates.

Chemical Properties

Molecular Weight	458.45
Formula	C20H21F3N2O5S
Cas No.	865273-97-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (545.32 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1813 mL	10.9063 mL	21.8126 mL	109.0631 mL
5 mM	0.4363 mL	2.1813 mL	4.3625 mL	21.8126 mL
10 mM	0.2181 mL	1.0906 mL	2.1813 mL	10.9063 mL
20 mM	0.1091 mL	0.5453 mL	1.0906 mL	5.4532 mL
50 mM	0.0436 mL	0.2181 mL	0.4363 mL	2.1813 mL
100 mM	0.0218 mL	0.1091 mL	0.2181 mL	1.0906 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ERAP1 IN 1ERAP1inhibitERAP1-IN-1ERAP-1-IN-1InhibitoraminopeptidaseERAP1IN1reticulumendoplasmic