Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $2,420 | 1-2 weeks | |
50 mg | $3,180 | 1-2 weeks | |
100 mg | $4,300 | 1-2 weeks |
Description | Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM. |
Targets&IC50 | DBH:107 nM |
In vitro | Etamicastat inhibits the hERG current amplitude with an IC50 value of 44 μg/mL. |
In vivo | Etamicastat (50 mg/kg;?a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats.Etamicastat (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels. |
Alias | BIA 5-453 |
Molecular Weight | 311.35 |
Formula | C14H15F2N3OS |
Cas No. | 760173-05-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.