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Ethacizine hydrochloride

Catalog No. T11239Cas No. 57530-40-2
Alias NIK-244 hydrochloride, NIK-244, Ethacizin

Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity, and its effects are related to cardiac activity and can be used to study arrhythmias and myocardial infarction.

Ethacizine hydrochloride

Ethacizine hydrochloride

Purity: 98.08%
Catalog No. T11239Alias NIK-244 hydrochloride, NIK-244, EthacizinCas No. 57530-40-2
Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity, and its effects are related to cardiac activity and can be used to study arrhythmias and myocardial infarction.
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1 mg$71In Stock
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Purity:98.08%
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Product Introduction

Bioactivity
Description
Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity, and its effects are related to cardiac activity and can be used to study arrhythmias and myocardial infarction.
In vivo
Injecting Ethacizine hydrochloride (1-300 ug) directly into the SA node shows negative chronotropic, negative inotropic, and coronary vasodilator effects, as observed in PM preparations[2].
AliasNIK-244 hydrochloride, NIK-244, Ethacizin
Chemical Properties
Molecular Weight449.99
FormulaC22H28ClN3O3S
Cas No.57530-40-2
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (200.00 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2223 mL11.1114 mL22.2227 mL111.1136 mL
5 mM0.4445 mL2.2223 mL4.4445 mL22.2227 mL
10 mM0.2222 mL1.1111 mL2.2223 mL11.1114 mL
20 mM0.1111 mL0.5556 mL1.1111 mL5.5557 mL
50 mM0.0444 mL0.2222 mL0.4445 mL2.2223 mL
100 mM0.0222 mL0.1111 mL0.2222 mL1.1111 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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