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euphol

Catalog No. T5737 CAS 514-47-6

Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.

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euphol, CAS 514-47-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 84.00
5 mg	In stock	$ 198.00
10 mg	In stock	$ 347.00
25 mg	In stock	$ 626.00
50 mg	In stock	$ 888.00
100 mg	In stock	$ 1,220.00
500 mg	In stock	$ 2,430.00
1 mL * 10 mM (in DMSO)	In stock	$ 242.00

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Purity: 99.85%

Purity: 98%

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Description	Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.
In vivo	Oral treatment with euphol (30 and 100 mg/kg) reduced carrageenan-induced mechanical hyperalgesia. Likewise, euphol given through the spinal and intracerebroventricular routes prevented mechanical hyperalgesia induced by carrageenan. Euphol consistently blocked the mechanical hyperalgesia induced by complete Freund's adjuvant, keratinocyte-derived chemokine, interleukin-1β, interleukin-6 and tumor necrosis factor-alpha associated with the suppression of myeloperoxidase activity in the mouse paw. Oral treatment with euphol was also effective in preventing the mechanical nociceptive response induced by ligation of the sciatic nerve and also significantly reduced the levels and mRNA of cytokines/chemokines in both paw and spinal cord tissues following i.pl. injection of complete Freund's adjuvant. In addition, the pre-treatment with either CB?R or CB?R antagonists, as well as the knockdown gene of the CB?R and CB?R, significantly reversed the antinociceptive effect of euphol.
Animal Research	For the induction of inflammatory pain, mice received an intraplantar injection of 20 ml of carrageenan (300 ug/paw) under the surface of the right hindpaw.?To assess the systemic effect of drug treatment, mice received euphol (3, 30 or 100 ug/kg) or its vehicle (5% Tween 80 solution made in saline e 0.9% NaCl solution), 1 h before carrageenan injection.?Other group of mice received dexamethasone (0.5 mg/kg.) 1 h before carrageenan?injection that was used as positive control drug.?The development of mechanical hyperalgesia was evaluated at 1, 2, 4, 6, 8, 24 and 48 h time points, after drug pre-treatments.?In order to evaluate the possible site of action of euphol (central or peripheral), a separate group of animals received an i.pl.?injection of euphol (5, 10 or 30 ug/paw) 15 min prior carrageenan (300 ug/paw) administration.?Additional groups of animals received an intrathecal (1, 3 and 10 ug/site) or intracerebroventricular ?(0.3, 3 or 10 ug/site) injection of 5 ml of euphol, 15 min before the paw injection of carrageenan.?Compared the analgesic efficacy of euphol with different groups of standard analgesic drugs, as described previously: indomethacin (2 mg/kg), morphine (5 mg/kg.), gabapentin (70 mg/kg) and dipyrone (120 mg/kg).?All drugs were administered 1 h before i.pl.?carrageenan injection (300 ug/paw).?Mechanical hyperalgesia was evaluated at 1, 2, 4, 6, 8 and 24 h time points after carrageenan injection, and measured with VFH.
Source	Natural Products > Euphorbiaceae > Euphorbia

Molecular Weight	426.72
Formula	C30H50O
CAS No.	514-47-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.27 mg/mL (10 mM)

References and Literature

1. Dutra R C , Bento A F , Marcon R , et al. Euphol, a tetracyclic triterpene produces antinociceptive effects in inflammatory and neuropathic pain: The involvement of cannabinoid system[J]. Neuropharmacology, 2012, 63(4):593-605.

Related compound libraries

This product is contained In the following compound libraries：

Selected Plant-Sourced Compound Library Anti-Obesity Compound Library Terpene Natural Product Library Metabolism Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Fibrosis Compound Library Natural Product Library for HTS Anti-Aging Compound Library Chinese Pharmacopoeia Natural Product Library

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Keywords

euphol 514-47-6 Metabolism Others Lipase Endogenous Metabolite MAGL Inhibitor Monoacylglycerol lipase inhibit inhibitor

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