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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $40 | In Stock | |
2 mg | $57 | In Stock | |
5 mg | $89 | In Stock | |
10 mg | $143 | In Stock | |
25 mg | $253 | In Stock | |
50 mg | $397 | In Stock | |
100 mg | $613 | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1) |
In vitro | FEN1 Inhibitor C2 inhibition selectively impairs proliferation of colon cancer cells deficient in Cdc4 and Mre11a, both frequently mutated in colorectal cancers.?FEN1 has also emerged as a potential chemosensitizing target due to its role in LP-BER since it is critical for repair of MMS (methyl methanesulfonate)-induced alkylation damage, and its knockdown or inhibition increases sensitivity to TMZ (temozolomide) in glioblastoma and colorectal cancer cell lines. |
Alias | FEN1 Inhibitor C2 |
Molecular Weight | 232.24 |
Formula | C12H12N2O3 |
Cas No. | 1995893-58-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (430.59 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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