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FT-1518
😃Good
Catalog No. T11328Cas No. 1313026-58-2
FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research.
FT-1518
😃Good
Purity: 98.80%
Catalog No. T11328Cas No. 1313026-58-2
FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $89 | 6-8 weeks | |
| 25 mg | $618 | 6-8 weeks | |
| 50 mg | $945 | 6-8 weeks | |
| 100 mg | $1,689 | 6-8 weeks |
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Purity:98.80%
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Product Introduction
Bioactivity
Chemical Properties
| Description | FT-1518 is an orally available, selective and potent mTORC1 and mTORC2 inhibitor with anticancer and antitumor activity for cancer research. |
| In vitro | FT-1518 depicted very good growth inhibitory activity across a large panel of hematologic and solid tumor cell lines with most activities falling into low nanomolar range. mTOR kinase inhibition in cells, by FT-1518, resulted in more potent inhibition of the mTOR pathway biomarkers (mTORC 1 & 2 biomarkers [pAkt(S473) and pS6(S240/244) or p70 S6K), no inhibition of PI3K biomarker [pAkt(T308)], and improved anti-proliferative activity as compared with rapamycin. [1] |
| In vivo | FT-1518 showed high sustained tumor exposure and target Inhibition in a single oral dose xenograft model. FT-1518 exhibited dose-dependent and higher tumor growth inhibition (TGI) in multiple solid tumor xenografts compared with rapalogs and is poised to enter the clinic with a favorable toxicology profile. [1] |
| Molecular Weight | 394.47 |
| Formula | C20H26N8O |
| Cas No. | 1313026-58-2 |
| Smiles | N=1C=C(N=CC1N)C2=NC(=NC3=C2N=CN3C(CC)CC)N4CC5OC(C4)CC5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 2 mg/mL (5.07 mM), Sonication is recommended. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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