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Galocitabine

🥰Excellent
Catalog No. T27399Cas No. 124012-42-6
Alias RO-09-1390, RO-091390, RO091390, RO 091390, Neofrutulon

Galocitabine (Neofrutulon), a thymidylate synthase inhibitor, is used potentially for the treatment of cancer.

Galocitabine

Galocitabine

🥰Excellent
Purity: 99.86%
Catalog No. T27399Alias RO-09-1390, RO-091390, RO091390, RO 091390, NeofrutulonCas No. 124012-42-6
Galocitabine (Neofrutulon), a thymidylate synthase inhibitor, is used potentially for the treatment of cancer.
Pack SizePriceAvailabilityQuantity
1 mg$118In Stock
5 mg$287In Stock
10 mg$392In Stock
25 mg$593In Stock
50 mg$798In Stock
100 mg$1,050In Stock
200 mg$1,390In Stock
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Purity:99.86%
ee:100%
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Product Introduction

Bioactivity
Description
Galocitabine (Neofrutulon), a thymidylate synthase inhibitor, is used potentially for the treatment of cancer.
In vivo
We performed 4-week toxicity studies of capecitabine (N(4)-pentyloxycarbonyl-5'-deoxy-5-fluorouridine), galocitabine (trimethoxybenzyl-5'-deoxy-5-fluorocytidine), 4 different fluoropyrimidine carbamate analogs. Four-week toxicity data for capecitabine in rats and mice were also obtained for comparison. Capecitabine, galocitabine, butyl, and isopentyl analogs showed similar toxicities in hematopoietic and intestinal organs at 1.0 mmol/kg. These compounds showed slight toxicity at 0.5 mmol/kg and no toxicity at 0.1 mmol/kg. [1]
AliasRO-09-1390, RO-091390, RO091390, RO 091390, Neofrutulon
Chemical Properties
Molecular Weight439.39
FormulaC19H22FN3O8
Cas No.124012-42-6
SmilesO[C@H]1[C@@H](O[C@H](C)[C@H]1O)N2C(=O)N=C(NC(=O)C3=CC(OC)=C(OC)C(OC)=C3)C(F)=C2
Relative Density.1.52 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (113.79 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2759 mL11.3794 mL22.7588 mL113.7941 mL
5 mM0.4552 mL2.2759 mL4.5518 mL22.7588 mL
10 mM0.2276 mL1.1379 mL2.2759 mL11.3794 mL
20 mM0.1138 mL0.5690 mL1.1379 mL5.6897 mL
50 mM0.0455 mL0.2276 mL0.4552 mL2.2759 mL
100 mM0.0228 mL0.1138 mL0.2276 mL1.1379 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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