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GDC-0339

Name: GDC-0339
Brand: TargetMol
SKU: T15376
Price: 99 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T15376Cas No. 1428569-85-0

GDC-0339 is discovered as a potential treatment of multiple myeloma. GDC-0339 is an orally bioavailable and well-tolerated inhibitor of the pan-Pim kinase (Kis: 0.03 nM, 0.1 nM, and 0.02 nM for Pim1, Pim2, and Pim3, respectively).

GDC-0339

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Catalog No. T15376Cas No. 1428569-85-0

Pack Size	Price	Availability
25 mg	$1,650	10-14 weeks
50 mg	$2,150	10-14 weeks
100 mg	$3,730	10-14 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	GDC-0339 is discovered as a potential treatment of multiple myeloma. GDC-0339 is an orally bioavailable and well-tolerated inhibitor of pan-Pim kinase (Kis: 0.03 nM, 0.1 nM and 0.02 nM for Pim1, Pim2 and Pim3, respectively).
Targets&IC50	Pim2:0.1 nM(Ki), Pim3:0.02 nM(Ki), Pim1:0.03 nM(Ki)
In vitro	GDC-0339 is cytostatic (IC50 of 0.1 μM for MM.1S cells). GDC-0339 treatment shows a constellation of Pim downstream signaling events. Which is consistent with inhibition of Pim kinases[2].
In vivo	GDC-0339 has a half-life of t1/2=0.9 h. GDC-0339 (1-300 mg/kg; p.o; daily; for 21 days) is potently in RPMI8226 and MM.1S human multiple myeloma xenograft mouse models [2].

Chemical Properties

Molecular Weight	465.5
Formula	C₂₀H₂₂F₃N₇OS
Cas No.	1428569-85-0
Smiles	Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1N1CC[C@@H](N)[C@H](F)CC1
Relative Density.	1.61 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (107.41 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1482 mL	10.7411 mL	21.4823 mL	107.4114 mL
5 mM	0.4296 mL	2.1482 mL	4.2965 mL	21.4823 mL
10 mM	0.2148 mL	1.0741 mL	2.1482 mL	10.7411 mL
20 mM	0.1074 mL	0.5371 mL	1.0741 mL	5.3706 mL
50 mM	0.0430 mL	0.2148 mL	0.4296 mL	2.1482 mL
100 mM	0.0215 mL	0.1074 mL	0.2148 mL	1.0741 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc