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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $48 | 5 days | |
5 mg | $113 | 7-10 days | |
10 mg | $189 | 7-10 days | |
25 mg | $372 | 7-10 days | |
50 mg | $562 | 7-10 days | |
100 mg | $790 | 7-10 days | |
500 mg | $1,670 | 7-10 days |
Description | GGTI-2418 is a highly potent, competitive, and selective inhibitor of geranylgeranyltransferase I (GGTase I), exhibiting inhibitory activities with IC50 values of 9.5 nM for GGTase I and 53 μM for FTase, respectively. Additionally, it enhances p27(Kip1) expression and induces significant regression of breast tumors. |
Targets&IC50 | GGTase I:9.5 nM, FTase:53 μM |
In vitro | In HeLa cells, GGTI-2418 (10-15 μM; 16 hours) can delocalize FBXL2 and stabilize IP3R3[2]. |
In vivo | GGTI-2418 (100 mg/kg daily; 5 days) induces regression of ErbB2-driven mammary tumors in ErbB2 transgenic mice. GGTI-2418 inhibits the geranylgeranylation of Rap1, significantly reduces Akt S473 phosphorylation, and upregulates p27 levels in vivo. Additionally, GGTI-2418 (100 mg/kg daily or 200 mg/kg every third day; 15 days) significantly inhibits the growth of MDA-MB-231 breast tumor xenografts in nude mice. |
Alias | GGTI2418, GGT 2418 |
Molecular Weight | 441.52 |
Formula | C23H31N5O4 |
Cas No. | 501010-06-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (226.49 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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