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Iganidipine

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Catalog No. T15553Cas No. 119687-33-1
Alias NKY 722

Iganidipine(NKY 722) is a new water-soluble Ca2+ antagonist with antihypertensive activity for research and neurological related diseases.

Iganidipine

Iganidipine

🥰Excellent
Purity: 96.85%
Catalog No. T15553Alias NKY 722Cas No. 119687-33-1
Iganidipine(NKY 722) is a new water-soluble Ca2+ antagonist with antihypertensive activity for research and neurological related diseases.
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1 mg$700In Stock
5 mg$1,800In Stock
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Purity:96.85%
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Product Introduction

Bioactivity
Description
Iganidipine(NKY 722) is a new water-soluble Ca2+ antagonist with antihypertensive activity for research and neurological related diseases.
In vivo
After a single administration, Iganidipine (0.03% solution) significantly increases optic nerve head (ONH) tissue blood velocity (NBONH) by 8 to 10% in treated eyes (p<0.05). Additionally, following twice-daily administration for 7, 14, or 21 days in rabbits, it results in a significant increase of 18 to 35% in NBONH (p<0.05). In monkeys, after 7 days of twice-daily administration, both 0.03% and 0.1% Iganidipine significantly increase NBONH in treated eyes by 20% and 41%, respectively (p<0.05)[1].
AliasNKY 722
Chemical Properties
Molecular Weight526.62
FormulaC28H38N4O6
Cas No.119687-33-1
SmilesO=C(C1=C(C)NC(C)=C(C1C2=CC([N+]([O-])=O)=CC=C2)C(OCC(C)(CN3CCN(CC3)CC=C)C)=O)OC
Relative Density.1.31g/cm3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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