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IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity. IHMT-MST1-58 can be used to study type 1 or type 2 diabetes.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $97 | In Stock | |
5 mg | $247 | In Stock | |
10 mg | $397 | In Stock | |
25 mg | $663 | In Stock | |
50 mg | $945 | In Stock | |
100 mg | $1,280 | In Stock | |
500 mg | $2,570 | In Stock |
Description | IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity. IHMT-MST1-58 can be used to study type 1 or type 2 diabetes. |
Targets&IC50 | MST1:23 nM, MST2:652 nM, MST1:240 nM(kd) |
In vitro | IHMT-MST1-58 (0.1-10 μM; 1-2 h) inhibits the phosphorylation of MST1 in vitro.[1] IHMT-MST1-58 (0.03, 0.1 and 0.3 μM; 48 h) exhibits a significant protective effect of β cells from the damage caused by inflammatory cytokines.[1] |
In vivo | IHMT-MST1-58 (p.o, 50 mg/kg/day, QD) combined with metformin resulted in the reduction of fasting blood glucose, demonstrating the protective effect on β cells and decrease in hemoglobin A1c levels in the STZ-induced T1D/T2D mouse models.[1] |
Molecular Weight | 438.5 |
Formula | C21H22N6O3S |
Cas No. | 2414484-25-4 |
Smiles | CN1C=2C(N(C)C(=O)C1C3=C(C)C=CC=C3)=CN=C(NC4=CC=C(S(N)(=O)=O)C=C4)N2 |
Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90 mg/mL (205.25 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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