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Isovalerylshikonin
Catalog No. TN2447Cas No. 76549-35-4
Isovalerylshikonin is a natural product from Onosma heterophylla and Arnebia euchroma.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $229 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Isovalerylshikonin is a natural product from Arnebia euchroma |
| In vitro | Isovalerylshikonin exhibited marginal antibacterial activity against drug-resistant Staphylococcus aureus RN4220, with an MIC of 16 mg/L[1]. |
| In vivo | A peritonitis/sepsis model was employed to test the in vivo synergistic activity of IVS and STM. IVS synergistically decreased the bacteria count with STM in peritoneal, spleen and liver, and increased mouse survival with STM in 7 days. The acute toxicity of IVS was tested, and the LD50 of IVS with a single exposure was 2.584 g/kg in mice. Overall, isovalerylshikonin, a low toxicity resistance-modifying agent, exhibited synergistic antibacterial activities in vitro and in vivo against drug-resistant S. aureus. The effects were mediated by suppression of msrA mRNA expression and bacterial efflux[1]. |
| Molecular Weight | 372.41 |
| Formula | C21H24O6 |
| Cas No. | 76549-35-4 |
| Storage | store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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