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Thioquinapiperifil dihydrochloride

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Purity:98.73%

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COA HPLC HNMR

Thioquinapiperifil dihydrochloride

Catalog No. T9773Cas No. 204077-66-7

Thioquinapiperifil dihydrochloride is a phosphodiesterase (PDE-5) inhibitor (IC50: 0.074 nM) that is potent, selective and non-competitive for investigational maturation.

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Pack Size	Price	Availability
1 mg	$155	In Stock
5 mg	$383	In Stock
10 mg	$569	In Stock
25 mg	$917	In Stock
50 mg	$1,250	In Stock
100 mg	$1,690	In Stock
500 mg	$3,380	In Stock
1 mL x 10 mM (in DMSO)	$441	In Stock

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Product Introduction

Bioactivity

Description	Thioquinapiperifil dihydrochloride is a phosphodiesterase (PDE-5) inhibitor (IC50: 0.074 nM) that is potent, selective and non-competitive for investigational maturation.
In vitro	Thioquinapiperifil dihydrochloride (KF31327) (0.1-10 μM) inhibits platelet aggregation in a concentration-dependent manner. In the absence of nitroglycerin, higher concentrations of 1 and 10 μM of KF31327 are inhibits platelet aggregation in a concentration-dependent manner.[2] Thioquinapiperifil dihydrochloride (KF31327) shows a significant increase in cyclic GMP at 10 μM. After 5 min incubation, the mean cyclic GMP levels of KF31327-treated cells is 0.95±0.17 pmol/10 8 cells.[2]
Alias	KF-31327

Chemical Properties

Molecular Weight	485.05
Formula	C24H29ClN6OS
Cas No.	204077-66-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 112.5 mg/mL (215.7 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0616 mL	10.3082 mL	20.6164 mL	103.0822 mL
5 mM	0.4123 mL	2.0616 mL	4.1233 mL	20.6164 mL
10 mM	0.2062 mL	1.0308 mL	2.0616 mL	10.3082 mL
20 mM	0.1031 mL	0.5154 mL	1.0308 mL	5.1541 mL
50 mM	0.0412 mL	0.2062 mL	0.4123 mL	2.0616 mL
100 mM	0.0206 mL	0.1031 mL	0.2062 mL	1.0308 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc