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KPT-251

🥰Excellent
Catalog No. T24269Cas No. 1388841-50-6
Alias KPT251

KPT-251 is a selective nuclear export inhibitor.

KPT-251

KPT-251

🥰Excellent
Purity: 98.54%
Catalog No. T24269Alias KPT251Cas No. 1388841-50-6
KPT-251 is a selective nuclear export inhibitor.
Pack SizePriceAvailabilityQuantity
1 mg$148In Stock
5 mg$336In Stock
10 mg$497In Stock
25 mg$793In Stock
50 mg$1,130In Stock
1 mL x 10 mM (in DMSO)$361In Stock
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Purity:98.54%
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Product Introduction

Bioactivity
Description
KPT-251 is a selective nuclear export inhibitor.
In vitro
Treatment of Glioblastoma neurosphere cultures with KPT-251 revealed dose-responsive growth inhibition in seven patient-derived GBM lines[1].
In vivo
In a systemic metastasis model, following intracardiac injection of PCb2 cells, 80% (8/10) of controls, 10% (1/10) Selinexor- and 20% (2/10) KPT-251-treated animals developed radiographic evidence of lytic bone lesions. Similarly, after intra-tibial injection, the lytic areas were higher in controls than in Selinexor and KPT-251 groups. Analogously, the serum levels of osteoclast markers (mTRAP and type I collagen fragment, CTX), were significantly higher in controls than in Selinexor- and KPT-251-treated animals. Importantly, overall survival and disease-free survival were significantly higher in Selinexor- and KPT-251-treated animals when compared to controls[2].
AliasKPT251
Chemical Properties
Molecular Weight375.23
FormulaC14H7F6N5O
Cas No.1388841-50-6
SmilesC(F)(F)(F)C=1C=C(C=C(C(F)(F)F)C1)C2=NN(/C=C\C3=NN=CO3)C=N2
Relative Density.1.58 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 65 mg/ml (173.23 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6650 mL13.3252 mL26.6503 mL133.2516 mL
5 mM0.5330 mL2.6650 mL5.3301 mL26.6503 mL
10 mM0.2665 mL1.3325 mL2.6650 mL13.3252 mL
20 mM0.1333 mL0.6663 mL1.3325 mL6.6626 mL
50 mM0.0533 mL0.2665 mL0.5330 mL2.6650 mL
100 mM0.0267 mL0.1333 mL0.2665 mL1.3325 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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