Shopping Cart
- Remove All
- Your shopping cart is currently empty
KPT-251 is a selective nuclear export inhibitor.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $148 | In Stock | |
5 mg | $336 | In Stock | |
10 mg | $497 | In Stock | |
25 mg | $793 | In Stock | |
50 mg | $1,130 | In Stock | |
1 mL x 10 mM (in DMSO) | $361 | In Stock |
Description | KPT-251 is a selective nuclear export inhibitor. |
In vitro | Treatment of Glioblastoma neurosphere cultures with KPT-251 revealed dose-responsive growth inhibition in seven patient-derived GBM lines[1]. |
In vivo | In a systemic metastasis model, following intracardiac injection of PCb2 cells, 80% (8/10) of controls, 10% (1/10) Selinexor- and 20% (2/10) KPT-251-treated animals developed radiographic evidence of lytic bone lesions. Similarly, after intra-tibial injection, the lytic areas were higher in controls than in Selinexor and KPT-251 groups. Analogously, the serum levels of osteoclast markers (mTRAP and type I collagen fragment, CTX), were significantly higher in controls than in Selinexor- and KPT-251-treated animals. Importantly, overall survival and disease-free survival were significantly higher in Selinexor- and KPT-251-treated animals when compared to controls[2]. |
Alias | KPT251 |
Molecular Weight | 375.23 |
Formula | C14H7F6N5O |
Cas No. | 1388841-50-6 |
Smiles | C(F)(F)(F)C=1C=C(C=C(C(F)(F)F)C1)C2=NN(/C=C\C3=NN=CO3)C=N2 |
Relative Density. | 1.58 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 65 mg/ml (173.23 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.