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Lalistat 1

🥰Excellent
Catalog No. T38344Cas No. 501104-16-1
Alias ZINC795230

Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and IgA1 protease for H. influenzae. Lalistat 1 can be used in studies about niemann-pick type C diseases.

Lalistat 1

Lalistat 1

🥰Excellent
Purity: 99.7%
Catalog No. T38344Alias ZINC795230Cas No. 501104-16-1
Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and IgA1 protease for H. influenzae. Lalistat 1 can be used in studies about niemann-pick type C diseases.
Pack SizePriceAvailabilityQuantity
5 mg$46In Stock
10 mg$63In Stock
25 mg$98In Stock
50 mg$148In Stock
100 mg$217In Stock
500 mgInquiryIn Stock
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Purity:99.7%
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Product Introduction

Bioactivity
Description
Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and IgA1 protease for H. influenzae. Lalistat 1 can be used in studies about niemann-pick type C diseases.
Targets&IC50
LAL (human):68 nM (IC50)
In vitro
Lalistat 1 (0-100 μM) inhibits IgA1P B1 and B2 dose-dependently, achieving near-complete inhibition at 50 μM and complete inhibition at 100 μM [1]. Additionally, Lalistat 1 reduces cholesterol accumulation in lysosome-like reservoirs of GM03123 human fibroblasts lacking NPC1 [2].
AliasZINC795230
Chemical Properties
Molecular Weight298.36
FormulaC12H18N4O3S
Cas No.501104-16-1
SmilesO=C(Oc1nsnc1N1CCCCC1)N1CCOCC1
Relative Density.1.356 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 20 mg/mL
DMSO: 45 mg/mL (150.82 mM), Sonication is recommended.
DMF: 20 mg/mL
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3517 mL16.7583 mL33.5166 mL167.5828 mL
5 mM0.6703 mL3.3517 mL6.7033 mL33.5166 mL
10 mM0.3352 mL1.6758 mL3.3517 mL16.7583 mL
20 mM0.1676 mL0.8379 mL1.6758 mL8.3791 mL
50 mM0.0670 mL0.3352 mL0.6703 mL3.3517 mL
100 mM0.0335 mL0.1676 mL0.3352 mL1.6758 mL

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