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Lalistat 1

Lalistat 1
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Purity:99.7%
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Lalistat 1

Catalog No. T38344Cas No. 501104-16-1
Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and IgA1 protease for H. influenzae. Lalistat 1 can be used in studies about niemann-pick type C diseases.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$46In Stock
10 mg$63In Stock
25 mg$98In Stock
50 mg$148In Stock
100 mg$217In Stock
500 mgInquiryIn Stock
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Product Introduction

Bioactivity
Description
Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and IgA1 protease for H. influenzae. Lalistat 1 can be used in studies about niemann-pick type C diseases.
In vitro
Lalistat 1 (0-100 μM) dose-dependently inhibits IgA1P B1 and B2, almost completely at 50 μM and completely at 100 μM [1].Lalistat 1 reduces cholesterol accumulation in lysosome-like reservoirs of GM03123 human fibroblasts lacking NPC1 [2].
AliasZINC795230
Chemical Properties
Molecular Weight298.36
FormulaC12H18N4O3S
Cas No.501104-16-1
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Ethanol: 20 mg/mL
DMSO: 45 mg/mL (150.82 mM)
DMF: 20 mg/mL
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3517 mL16.7583 mL33.5166 mL167.5828 mL
5 mM0.6703 mL3.3517 mL6.7033 mL33.5166 mL
10 mM0.3352 mL1.6758 mL3.3517 mL16.7583 mL
20 mM0.1676 mL0.8379 mL1.6758 mL8.3791 mL
50 mM0.0670 mL0.3352 mL0.6703 mL3.3517 mL
100 mM0.0335 mL0.1676 mL0.3352 mL1.6758 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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