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Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and IgA1 protease for H. influenzae. Lalistat 1 can be used in studies about niemann-pick type C diseases.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $46 | In Stock | |
10 mg | $63 | In Stock | |
25 mg | $98 | In Stock | |
50 mg | $148 | In Stock | |
100 mg | $217 | In Stock | |
500 mg | Inquiry | In Stock |
Description | Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and IgA1 protease for H. influenzae. Lalistat 1 can be used in studies about niemann-pick type C diseases. |
Targets&IC50 | LAL (human):68 nM (IC50) |
In vitro | Lalistat 1 (0-100 μM) inhibits IgA1P B1 and B2 dose-dependently, achieving near-complete inhibition at 50 μM and complete inhibition at 100 μM [1]. Additionally, Lalistat 1 reduces cholesterol accumulation in lysosome-like reservoirs of GM03123 human fibroblasts lacking NPC1 [2]. |
Alias | ZINC795230 |
Molecular Weight | 298.36 |
Formula | C12H18N4O3S |
Cas No. | 501104-16-1 |
Smiles | O=C(Oc1nsnc1N1CCCCC1)N1CCOCC1 |
Relative Density. | 1.356 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 20 mg/mL DMSO: 45 mg/mL (150.82 mM), Sonication is recommended. DMF: 20 mg/mL | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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