Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

LCC-12 formate

😃Good
Catalog No. T83866

LCC-12, a derivative of the biguanide metformin, acts as a copper (II) chelator. It efficiently forms a monomeric bond with copper (II) and at 20 µM, it mitigates hydrogen peroxide-induced oxidation from NADH to NAD+. At a concentration of 10 µM, LCC-12 significantly reduces the secretion of cytokines IL-1β, IL-2, IL-6, IL-8, and TNF-α, along with the downregulation of JAK2, STAT2, and IL-1 receptor-associated kinase 4 (IRAK4) in primary human cytokine-activated monocyte-derived macrophages (MDMs). Additionally, it decreases the presence of CD80+ and CD86+ within these macrophages at 10 µM. When administered at 0.3 mg/kg per day, LCC-12 enhances survival rates in mouse models exposed to sepsis, triggered either by lipopolysaccharide (LPS) or cecal ligation and puncture.

LCC-12 formate

LCC-12 formate

😃Good
Catalog No. T83866
LCC-12, a derivative of the biguanide metformin, acts as a copper (II) chelator. It efficiently forms a monomeric bond with copper (II) and at 20 µM, it mitigates hydrogen peroxide-induced oxidation from NADH to NAD+. At a concentration of 10 µM, LCC-12 significantly reduces the secretion of cytokines IL-1β, IL-2, IL-6, IL-8, and TNF-α, along with the downregulation of JAK2, STAT2, and IL-1 receptor-associated kinase 4 (IRAK4) in primary human cytokine-activated monocyte-derived macrophages (MDMs). Additionally, it decreases the presence of CD80+ and CD86+ within these macrophages at 10 µM. When administered at 0.3 mg/kg per day, LCC-12 enhances survival rates in mouse models exposed to sepsis, triggered either by lipopolysaccharide (LPS) or cecal ligation and puncture.
Pack SizePriceAvailabilityQuantity
1 mg$97 Backorder
5 mg$437 Backorder
10 mg$773 Backorder
Bulk & Custom
Add to Cart
Questions
View More
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
LCC-12, a derivative of the biguanide metformin, acts as a copper (II) chelator. It efficiently forms a monomeric bond with copper (II) and at 20 µM, it mitigates hydrogen peroxide-induced oxidation from NADH to NAD+. At a concentration of 10 µM, LCC-12 significantly reduces the secretion of cytokines IL-1β, IL-2, IL-6, IL-8, and TNF-α, along with the downregulation of JAK2, STAT2, and IL-1 receptor-associated kinase 4 (IRAK4) in primary human cytokine-activated monocyte-derived macrophages (MDMs). Additionally, it decreases the presence of CD80+ and CD86+ within these macrophages at 10 µM. When administered at 0.3 mg/kg per day, LCC-12 enhances survival rates in mouse models exposed to sepsis, triggered either by lipopolysaccharide (LPS) or cecal ligation and puncture.
Chemical Properties
Molecular Weight414.55
FormulaC16H36N10.CH2O2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 30 mg/mL (72.37 mM), Sonication is recommended.
PBS pH 7.2: 10 mg/mL (24.12 mM), Sonication is recommended.
DMSO: 30 mg/mL (72.37 mM), Sonication is recommended.
DMF: 30 mg/mL (72.37 mM), Sonication is recommended.
Solution Preparation Table
PBS pH 7.2/Ethanol/DMSO/DMF
1mg5mg10mg50mg
1 mM2.4123 mL12.0613 mL24.1225 mL120.6127 mL
5 mM0.4825 mL2.4123 mL4.8245 mL24.1225 mL
10 mM0.2412 mL1.2061 mL2.4123 mL12.0613 mL
20 mM0.1206 mL0.6031 mL1.2061 mL6.0306 mL
Ethanol/DMSO/DMF
1mg5mg10mg50mg
50 mM0.0482 mL0.2412 mL0.4825 mL2.4123 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy LCC-12 formate | purchase LCC-12 formate | LCC-12 formate cost | order LCC-12 formate | LCC-12 formate chemical structure | LCC-12 formate formula | LCC-12 formate molecular weight