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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | LCKLSL hydrochloride, an N-terminal hexapeptide and competitive annexin A2 (AnxA2) inhibitor, effectively disrupts the interaction between tissue plasminogen activator (tPA) and AnxA2. It additionally hinders plasmin generation and exhibits anti-angiogenic properties [1]. |
In vitro | In retinal microvascular endothelial cells (RMVEC), treatment with LCKLSL hydrochloride (0-2 mg) inhibits plasminogen activator production and suppresses VEGF-induced tPA activity under hypoxic conditions [1]. |
In vivo | LCKLSL hydrochloride has demonstrated inhibitory effects on angiogenic responses in two in vivo angiogenesis models (chicken chorioallantoic membrane and mouse matrigel plug assay). Treatment with LCKLSL hydrochloride peptides significantly reduced vascular length. At a concentration of 5 μg/mL, the peptide notably decreased the number of vascular branches, junctions, and tips [1]. |
Molecular Weight | 712.34 |
Formula | C30H58ClN7O8S |
Cas No. |
Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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