Shopping Cart
- Remove All
Your shopping cart is currently empty
LCKLSL hydrochloride
🥰Excellent
Catalog No. T78015
LCKLSL hydrochloride is a hexapeptide compound and competitive inhibitor of membrane-bound protein A2 (AnxA2) with potential anti-angiogenic activity that inhibits the development of autoimmune encephalomyelitis (EAE) in mice.
LCKLSL hydrochloride
🥰Excellent
Catalog No. T78015
LCKLSL hydrochloride is a hexapeptide compound and competitive inhibitor of membrane-bound protein A2 (AnxA2) with potential anti-angiogenic activity that inhibits the development of autoimmune encephalomyelitis (EAE) in mice.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $84 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $372 | In Stock | |
| 25 mg | $689 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "LCKLSL hydrochloride"
Dexamethasone acetate
NSC 39471, Dexamethasone 21-acetate, Dexamethasone 17-acetate, Dexamethason acetate
T09471177-87-3
Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones.
- $45
Size
QTY
Amcinonide
Cited
CL-34699
T026151022-69-6
Amcinonide (CL-34699) is a Corticosteroid. The mechanism of action of amcinonide is as a Corticosteroid Hormone Receptor Agonist.
- $35
Size
QTY
CitedTimonacic
Thioproline, Thiazolidine-4-carboxylic acid, Hepalidine, Detoxepa, 1,3-Thiazolidine-4-carboxylic acid
T0221444-27-9
Timonacic (Thioproline) has been used in trials studying the treatment of HIV Infections.
- $29
Size
QTY
Hydrocortisone 17-butyrate
Hydrocortisone butyrate, Cortisol 17-butyrate
T027013609-67-1
Hydrocortisone 17-butyrate (Cortisol 17-butyrate) is a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects.
- $29
Size
QTY
PY-60
T95662765218-56-0
PY-60 can effectively activate YAP transcriptional activity against annexin A2 (ANXA2) (Kd value of 1.4 µM). PY-60 activates a pro-proliferative, YAP-dependent transcriptional program in adult animals that are able to remodel the epidermis through proliferation.
- $116
Size
QTY
Hydrocortisone acetate
Hydrocortisone 21-acetate, Cortisol 21-acetate
T124350-03-3
Hydrocortisone acetate (Cortisol 21-acetate) is the synthetic acetate salt form of hydrocortisone, a corticosteroid with anti-inflammatory and immunosuppressive properties.
- $47
Size
QTY
LCKLSL acetate
LCKLSL acetate(533902-29-3 free base)
TP2482
LCKLSL acetate is a competitive annexin A2 (AnxA2) inhibitor. LCKLSL acetate potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2 and the generation of plasmin. LCKLSL acetate has anti-angiogenic roles.
- $112
Size
QTY
Select Batch
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | LCKLSL hydrochloride is a hexapeptide compound and competitive inhibitor of membrane-bound protein A2 (AnxA2) with potential anti-angiogenic activity that inhibits the development of autoimmune encephalomyelitis (EAE) in mice. |
| In vitro | In human retinal microvascular endothelial cells (RMVEC), treatment with LCKLSL hydrochloride (0-2 mg) inhibited the production of fibrinolytic enzymes and suppressed VEGF-induced tPA activity under hypoxic conditions. [1] |
| In vivo | In two in vivo models of angiogenesis (chicken chorioallantoic membrane and mouse stromal plug assay), the application of LCKLSL hydrochloride showed an inhibitory effect on the angiogenic response. After LCKLSL hydrochloride peptide treatment, the length of blood vessels was significantly shortened. At a dose of 5 μg/mL, LCKLSL hydrochloride peptide significantly reduced the number of branches, junctions, and endpoints of vessels. [1] |
| Molecular Weight | 712.34 |
| Formula | C30H58ClN7O8S |
| Smiles | CC(C)C[C@H](N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)O.Cl |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 8 mg/mL (11.23 mM), Sonication is recommended. DMSO: 20 mg/mL (28.08 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy LCKLSL hydrochloride | purchase LCKLSL hydrochloride | LCKLSL hydrochloride cost | order LCKLSL hydrochloride | LCKLSL hydrochloride chemical structure | LCKLSL hydrochloride in vivo | LCKLSL hydrochloride in vitro | LCKLSL hydrochloride formula | LCKLSL hydrochloride molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.