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LCKLSL acetate
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Catalog No. TP2482
Alias LCKLSL acetate(533902-29-3 free base)
LCKLSL acetate is a competitive annexin A2 (AnxA2) inhibitor. LCKLSL acetate potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2 and the generation of plasmin. LCKLSL acetate has anti-angiogenic roles.
LCKLSL acetate
😃Good
Catalog No. TP2482Alias LCKLSL acetate(533902-29-3 free base)
LCKLSL acetate is a competitive annexin A2 (AnxA2) inhibitor. LCKLSL acetate potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2 and the generation of plasmin. LCKLSL acetate has anti-angiogenic roles.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $112 | Backorder | |
| 5 mg | $227 | Backorder | |
| 10 mg | $412 | Backorder | |
| 25 mg | $686 | Backorder | |
| 50 mg | $977 | Backorder | |
| 100 mg | $1,320 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | LCKLSL acetate is a competitive annexin A2 (AnxA2) inhibitor. LCKLSL acetate potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2 and the generation of plasmin. LCKLSL acetate has anti-angiogenic roles. |
| In vitro | LCKLSL acetate (0-2 mg) inhibits the generation of plasmin and suppresses the VEGF-induced activity of tPA under hypoxic conditions in human retinal microvascular endothelial cells (RMVECs)[1]. |
| In vivo | In chicken chorioallantoic membrane and murine Matrigel plug assays, LCKLSL acetate significantly decreased the vascular length. LCKLSL acetate(5 μg/mL) significantly decreased the number of vascular branches, junctions and end-points[1]. |
| Alias | LCKLSL acetate(533902-29-3 free base) |
| Molecular Weight | 735.93 |
| Formula | C32H61N7O10S |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | H2O: 10 mg/mL (13.5 mM)  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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