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LCKLSL acetate

Catalog No. TP2482

LCKLSL acetate is a competitive annexin A2 (AnxA2) inhibitor. LCKLSL acetate potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2 and the generation of plasmin. LCKLSL acetate has anti-angiogenic roles.

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Pack Size	Price	Availability
1 mg	$112	Backorder
5 mg	$227	Backorder
10 mg	$412	Backorder
25 mg	$686	Backorder
50 mg	$977	Backorder
100 mg	$1,320	Backorder

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Product Introduction

Bioactivity

Description	LCKLSL acetate is a competitive annexin A2 (AnxA2) inhibitor. LCKLSL acetate potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2 and the generation of plasmin. LCKLSL acetate has anti-angiogenic roles.
In vitro	LCKLSL acetate (0-2 mg) inhibits the generation of plasmin and suppresses the VEGF-induced activity of tPA under hypoxic conditions in human retinal microvascular endothelial cells (RMVECs)[1].
In vivo	In chicken chorioallantoic membrane and murine Matrigel plug assays, LCKLSL acetate significantly decreased the vascular length. LCKLSL acetate(5 μg/mL) significantly decreased the number of vascular branches, junctions and end-points[1].
Alias	LCKLSL acetate(533902-29-3 free base)

Chemical Properties

Molecular Weight	735.93
Formula	C32H61N7O10S
Cas No.

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mg/mL (13.5 mM)

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
20 mM	0.0679 mL	0.3397 mL	0.6794 mL	3.3971 mL
50 mM	0.0272 mL	0.1359 mL	0.2718 mL	1.3588 mL
100 mM	0.0136 mL	0.0679 mL	0.1359 mL	0.6794 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc