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LM-1685
🥰Excellent
Catalog No. T32824Cas No. 416901-58-1
Alias LM1685, LM 1685
LM-1685 is a potent and selective inhibitor of COX-2 IN human monocytes and whole blood with IC50 of 0.65µM and IC50 = 4.3μM, respectively, and is a potential compound for the treatment of inflammation.
LM-1685
🥰Excellent
Purity: 99.39%
Catalog No. T32824Alias LM1685, LM 1685Cas No. 416901-58-1
LM-1685 is a potent and selective inhibitor of COX-2 IN human monocytes and whole blood with IC50 of 0.65µM and IC50 = 4.3μM, respectively, and is a potential compound for the treatment of inflammation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $210 | In Stock | |
| 5 mg | $497 | In Stock | |
| 10 mg | $678 | In Stock | |
| 25 mg | $953 | In Stock | |
| 50 mg | $1,180 | In Stock | |
| 100 mg | $1,500 | In Stock | |
| 200 mg | $1,960 | In Stock |
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Purity:99.39%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | LM-1685 is a potent and selective inhibitor of COX-2 IN human monocytes and whole blood with IC50 of 0.65µM and IC50 = 4.3μM, respectively, and is a potential compound for the treatment of inflammation. |
| Targets&IC50 | COX-2 (human monocytes):0.65 µM, COX-2 (whole blood):4.3μM |
| In vitro | We found that continuous exposure to cytostatic doses of CAI and LM-1685, a celecoxib analog, reduced the proliferation and survival of seven human cancer cell lines by at least one log (P < or = 0.001) over either agent alone. The supra-additive antiproliferative effects occurred throughout a range of LM-1685 doses (5-25 micromol/L) and paralleled a decrease in COX-2 activity as measured by prostaglandin E2 production. In these cells, treatment with LM-1685/CAI suppressed the extracellular signal-regulated kinase pathway within the first hour but ultimately results in high, sustained activation of ERK over a 9-day period (P = 0.0005). [1] |
| Alias | LM1685, LM 1685 |
| Molecular Weight | 377.84 |
| Formula | C18H16ClNO4S |
| Cas No. | 416901-58-1 |
| Smiles | C(N1C=2C(C=C1C(OC)=O)=CC(S(C)(=O)=O)=CC2)C3=CC=C(Cl)C=C3 |
| Relative Density. | 1.35 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 90.0 mg/mL (238.2 mM) Methanol: 0.9 mg/mL (2.3 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Methanol/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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