Shopping Cart
- Remove All
Your shopping cart is currently empty
LRE1
🥰Excellent
Catalog No. T15787Cas No. 1252362-53-0
LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase (sAC).
LRE1
🥰Excellent
Purity: 100%
Catalog No. T15787Cas No. 1252362-53-0
LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase (sAC).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $35 | In Stock | |
| 25 mg | $68 | In Stock | |
| 50 mg | $128 | In Stock | |
| 100 mg | $190 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "LRE1"
Forskolin
Cited
FSK, Colforsin, Coleonol
T293966575-29-9
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the heart, and has platelet anticoagulant and antihypertensive effects.
- $36
Size
QTY
CitedNB001
HTS 09836
T16275686301-48-4In house
NB001 (HTS 09836) is an adenyl cyclase 1 inhibitor that affects both neural and non-neural pain.
- $72
Size
QTY
2',5'-Dideoxyadenosine
T100666698-26-6
2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor, binding to the P-site with an IC50 of 3 μM.
- $33
Size
QTY
Wnt pathway inhibitor 3
T77502663213-98-7
Wnt pathway inhibitor 3 is a potent AC1 inhibitor (IC50: 45 nM) with antiproliferative activity, suitable for studies to ameliorate osteoarthritis in a mouse model of experimental osteoarthritis.
- $39
Size
QTY
NKY80
Adenylyl cyclase type V Inhibitor
T16333299442-43-6
NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues. NKY80 is a non-competitive inhibitor of adenylyl cyclase type V isoform (IC50s: 8.3 µM, 132 µM, and 1.7 mM for type V, III and II, respectively).
- $39
Size
QTY
AC1-IN-1
T600032762422-55-7
AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).
- $83
Size
QTY
ST034307
T16938133406-29-8
ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).
- $32
Size
QTY
α-MSH Cited
α-Melanocyte-Stimulating Hormone (MSH), amide, MSH, amide, CZEN-002
T7813581-05-5
α-MSH (MSH, amide) is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase.
- $52
Size
QTY
CitedSelect Batch
Purity:100%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | LRE1 is a specific and allosteric inhibitor of soluble adenylyl cyclase (sAC). |
| In vitro | LRE1 prevents sAC-dependent processes in cellular and physiological systems and facilitates exploration of the therapeutic potential of sAC inhibition. LRE1 binds to the bicarbonate activator binding site and suppresses soluble adenylyl cyclase (sAC) via a unique allosteric mechanism[1]. |
| Molecular Weight | 280.78 |
| Formula | C12H13ClN4S |
| Cas No. | 1252362-53-0 |
| Smiles | Nc1nc(Cl)cc(n1)N(Cc1cccs1)C1CC1 |
| Relative Density. | 1.496 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 112.5 mg/mL (400.7 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy LRE1 | purchase LRE1 | LRE1 cost | order LRE1 | LRE1 chemical structure | LRE1 in vitro | LRE1 formula | LRE1 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.