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NKY80

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Catalog No. T16333Cas No. 299442-43-6
Alias Adenylyl cyclase type V Inhibitor

NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues. NKY80 is a non-competitive inhibitor of adenylyl cyclase type V isoform (IC50s: 8.3 µM, 132 µM, and 1.7 mM for type V, III and II, respectively).

NKY80

NKY80

🥰Excellent
Purity: 100%
Catalog No. T16333Alias Adenylyl cyclase type V InhibitorCas No. 299442-43-6
NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues. NKY80 is a non-competitive inhibitor of adenylyl cyclase type V isoform (IC50s: 8.3 µM, 132 µM, and 1.7 mM for type V, III and II, respectively).
Pack SizePriceAvailabilityQuantity
2 mg$39In Stock
5 mg$62In Stock
10 mg$97In Stock
25 mg$197In Stock
50 mg$343In Stock
100 mg$523In Stock
200 mg$753In Stock
1 mL x 10 mM (in DMSO)$107In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues. NKY80 is a non-competitive inhibitor of adenylyl cyclase type V isoform (IC50s: 8.3 µM, 132 µM, and 1.7 mM for type V, III and II, respectively).
Targets&IC50
AC type V:8.3 μM, AC type III:132 μM, AC type II:1.7 mM
In vitro
NKY80 (20 μM) blocks the increase in LVP and ventricular cAMP levels[2]. NKY80 (20 μM; 2 hours) completely blocks the elevations in both cAMP content and renin release from isolated JG cells[3].
AliasAdenylyl cyclase type V Inhibitor
Chemical Properties
Molecular Weight229.23
FormulaC12H11N3O2
Cas No.299442-43-6
SmilesNC1=NC2=C(C=N1)C(=O)CC(C2)C1=CC=CO1
Relative Density.1.360 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 225 mg/mL (981.5 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.3624 mL21.8122 mL43.6243 mL218.1215 mL
5 mM0.8725 mL4.3624 mL8.7249 mL43.6243 mL
10 mM0.4362 mL2.1812 mL4.3624 mL21.8122 mL
20 mM0.2181 mL1.0906 mL2.1812 mL10.9061 mL
50 mM0.0872 mL0.4362 mL0.8725 mL4.3624 mL
100 mM0.0436 mL0.2181 mL0.4362 mL2.1812 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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