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ST034307
🥰Excellent
Catalog No. T16938Cas No. 133406-29-8
ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).
ST034307
🥰Excellent
Purity: 99.28%
Catalog No. T16938Cas No. 133406-29-8
ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $32 | In Stock | |
| 2 mg | $45 | In Stock | |
| 5 mg | $74 | In Stock | |
| 10 mg | $117 | In Stock | |
| 25 mg | $248 | In Stock | |
| 50 mg | $426 | In Stock | |
| 100 mg | $632 | In Stock | |
| 500 mg | $1,350 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $81 | In Stock |
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Purity:99.28%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM). |
| Targets&IC50 | AC type I:2.3 μM |
| In vitro | ST034307 obviously inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. ST034307 significantly inhibits the Ca2+/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of the MOR-mediated sensitization of AC1. ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 has no significant effects on wild-type HEK cells [1]. |
| In vivo | ST034307 shows an estimated median effective dose (E50) value for analgesia of 0.28 μg in the mouse pain model. ST034307 (0.25 μg) induces an obvious relief of CFA-induced inflammatory pain in mice [1]. |
| Molecular Weight | 297.95 |
| Formula | C10H4Cl4O2 |
| Cas No. | 133406-29-8 |
| Smiles | Clc1ccc2oc(cc(=O)c2c1)C(Cl)(Cl)Cl |
| Relative Density. | 1.674 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (167.81 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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