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Lumicitabine

Name: Lumicitabine
Brand: TargetMol
SKU: TQ0034
Rating: 4.5 (1 reviews)

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Catalog No. TQ0034Cas No. 1445385-02-3

Alias ALS-8176, ALS-008176

Lumicitabine (ALS-008176) is an RSV polymerase inhibitor.

Lumicitabine

😃Good

Catalog No. TQ0034Alias ALS-8176, ALS-008176Cas No. 1445385-02-3

Lumicitabine (ALS-008176) is an RSV polymerase inhibitor.

Pack Size	Price	Availability
5 mg	$347	7-10 days
10 mg	$541	7-10 days
1 mL x 10 mM (in DMSO)	$329	7-10 days

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	Lumicitabine (ALS-008176) is an RSV polymerase inhibitor.
In vivo	In an adult human challenge study, Lumicitabine has shown efficacy against RSV infection[1]. Lumicitabine solubility is adequate to support oral administration in solutions with a relatively low percentage of organic solvent and in aqueous suspensions. High levels of NMP and NTP are obtained following the oral administration of Lumicitabine to monkeys [2].
Animal Research	Rats: Lumicitabine is formulated as solutions in PEG400-based vehicles. Pharmacokinetic studies are conducted at 5 mg/kg and for oral PK studies, the prodrugs are administered at 5 mg/kg parent nucleoside equivalent doses. Blood samples are typically collected at various time points up to 24 h post dose for rat [2]. Monkeys: Lumicitabine is formulated as a solution in PEG400-based vehicles. Pharmacokinetic studies are conducted at 5 mg/kg and for oral PK studies, the prodrugs are administered at 5 mg/kg parent nucleoside equivalent doses. Blood samples are typically collected at various time points up to 12 h post dose for Monkeys [2].
Alias	ALS-8176, ALS-008176

Chemical Properties

Molecular Weight	433.86
Formula	C₁₈H₂₅ClFN₃O₆
Cas No.	1445385-02-3
Relative Density.	1.43 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 48 mg/mL (110.63 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3049 mL	11.5245 mL	23.0489 mL	115.2445 mL
5 mM	0.4610 mL	2.3049 mL	4.6098 mL	23.0489 mL
10 mM	0.2305 mL	1.1524 mL	2.3049 mL	11.5245 mL
20 mM	0.1152 mL	0.5762 mL	1.1524 mL	5.7622 mL
50 mM	0.0461 mL	0.2305 mL	0.4610 mL	2.3049 mL
100 mM	0.0230 mL	0.1152 mL	0.2305 mL	1.1524 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc