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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $490 | Backorder | |
50 mg | $1,950 | Backorder | |
100 mg | $3,800 | Backorder |
Description | LY255582 is a selective centrally active opioid receptor antagonist with high affinity for mu, delta and kappa receptors with Ki of 0.4 nM, 5.2, 2.0 nM, respectively. LY255582 inhibits diet-associated increases in mesolimbic dopamine levels and reduces consumption of food intake. LY255582 is commonly used in obesity research. LY255582 is a potential compound for the study of opioid receptor-mediated cell signaling. |
Targets&IC50 | μ:0.4 nM (Ki ), Delta:5.2 nM (Ki ), κ opioid:2 nM (Ki ) |
In vitro | LY255582 (40 μM, 24-72 h) biologically inhibits the viability of Huh7 and MHCC-97H cells.[1] |
In vivo | LY255582 (100 μg, i.c.v.) reduces food intake in rats [2].
LY255582 (15 mg/kg/d, s.c., once daily) decreases food intake and body weight gain in obese Zucker rats [3]. |
Alias | LY-255582, LY 255582 |
Molecular Weight | 345.52 |
Formula | C22H35NO2 |
Cas No. | 119193-09-8 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 13.5 mg/mL (39.1 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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