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M435-1279 is a UBE2T inhibitor that blocks UBE2T-mediated degradation of RACK1, thereby inhibiting the hyperactivation of the Wnt/β-catenin signaling pathway.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 29 € | In Stock | |
5 mg | 69 € | In Stock | |
10 mg | 110 € | In Stock | |
25 mg | 211 € | In Stock | |
50 mg | 316 € | In Stock | |
100 mg | 446 € | In Stock | |
200 mg | 628 € | In Stock | |
1 mL x 10 mM (in DMSO) | 82 € | In Stock |
Description | M435-1279 is a UBE2T inhibitor that blocks UBE2T-mediated degradation of RACK1, thereby inhibiting the hyperactivation of the Wnt/β-catenin signaling pathway. |
In vitro | M435-1279 (0, 2, 4, 8, 16, 31 μM; 48 h) significantly inhibits the growth of AGS, HGC27, and MKN45 cells. It also inhibits cell viability with IC50s of 16.8, 11.88, 7.76, and 6.93 μM for GES-1, HGC27, AGS, and MKN45 cells, respectively. M435-1279 (31 nM to 500 μM) binds to UBE2T protein with a KD value of 50.5 μM and (11.88 μM; 48 h) blocks the ubiquitination of RACK1, thereby inhibiting the hyperactivation of the Wnt/β-catenin pathway[1]. |
In vivo | M435-1279 (5 mg/kg/day; intratumor injection; 18 days) inhibits tumor growth and induces increased expression of RACK1 proteins while decreasing expression of Ki-67 and β-catenin proteins in intratumor tumors[1]. |
Molecular Weight | 419.47 |
Formula | C18H17N3O5S2 |
Cas No. | 1359431-16-5 |
Smiles | NS(=O)(=O)c1ccc(NC(=O)c2c(O)c3c4CCCCc4sc3[nH]c2=O)cc1 |
Relative Density. | 1.620 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45.0 mg/mL (107.3 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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