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Maresin 1
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Catalog No. T38047Cas No. 1268720-28-0
Maresin 1 is a small molecule compound biosynthesized by macrophages (MΦ) with significant anti-inflammatory activity that attenuates LPS-induced lung injury in mice by inhibiting neutrophil adhesion and decreasing the levels of pro-inflammatory cytokines, and stimulates intracellular Ca2+ production and secretion.
Maresin 1
😃Good
Catalog No. T38047Cas No. 1268720-28-0
Maresin 1 is a small molecule compound biosynthesized by macrophages (MΦ) with significant anti-inflammatory activity that attenuates LPS-induced lung injury in mice by inhibiting neutrophil adhesion and decreasing the levels of pro-inflammatory cytokines, and stimulates intracellular Ca2+ production and secretion.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 μg (277.4 µM * 100 μL in Ethanol) | $193 | 3-6 months | |
| 25 μg (277.4 µM * 100 μL in Ethanol) | $450 | 3-6 months | |
| 50 μg (277.4 µM * 100 μL in Ethanol) | $850 | 3-6 months | |
| 100 μg (277.4 µM * 100 μL in Ethanol) | $1,500 | 3-6 months |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Maresin 1 is a small molecule compound biosynthesized by macrophages (MΦ) with significant anti-inflammatory activity that attenuates LPS-induced lung injury in mice by inhibiting neutrophil adhesion and decreasing the levels of pro-inflammatory cytokines, and stimulates intracellular Ca2+ production and secretion. |
| In vitro | In addition to reducing the production of IL-1β, TNF-α, IL-6, and INF-γ, Maresin 1 (MaR1, 300 nM) also diminishes neutrophil migration and the generation of reactive oxygen species [2]. |
| In vivo | In a dose-dependent manner, Maresin 1 (MaR1) inhibits TRPV1 currents in neurons, blocking capsaicin-induced inward currents (IC50=0.49 nM), and alleviates inflammation and chemotherapy-induced neuropathic pain in mice [3].Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, iv) protects mice from acute DSS-induced colitis. Treatment with Maresin 1 (0.3 and 1 μg/animal, iv) significantly reduces macroscopic damage in the acute phase of DSS-induced colitis [2]. |
| Molecular Weight | 360.49 |
| Formula | C22H32O4 |
| Cas No. | 1268720-28-0 |
| Smiles | [C@H](/C=C/C=C/C=C\[C@H](C/C=C\C/C=C\CC)O)(C/C=C\CCC(O)=O)O |
| Relative Density. | 1.048 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMF: 50 mg/mL PBS (pH 7.2): 0.05 mg/mL Ethanol: 40 mg/mL (110.95 mM), Sonication is recommended. DMSO: 40 mg/mL (110.95 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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