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MC3138
🥰Excellent
Catalog No. T88662Cas No. 1844889-12-8
Alias MC 3138
MC3138 is a selective SIRT5 activator showing antitumor effects in PDAC cells.
MC3138
🥰Excellent
Catalog No. T88662Alias MC 3138Cas No. 1844889-12-8
MC3138 is a selective SIRT5 activator showing antitumor effects in PDAC cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $68 | In Stock | |
| 5 mg | $94 | In Stock | |
| 10 mg | $147 | In Stock | |
| 25 mg | $293 | In Stock | |
| 50 mg | $478 | In Stock | |
| 100 mg | $739 | In Stock | |
| 200 mg | $1,180 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $187 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | MC3138 is a selective SIRT5 activator showing antitumor effects in PDAC cells. |
| In vitro | MC3138 (10 μM, 24 h) inhibited lysine acetylation of GOT1 protein and decreased its enzyme activity in PDAC cells. Treated with MC3138 (50 μM, 24 or 48 h), MDA-MB-231 and CAL-62 cells, MC3138 reduced HIF-1α basal expression in MDA-MB-231 wt cells, but not in GLS1 silenced cells. [1] MC3138 decreased PDAC cell viability, with IC50 values ranging from 25.4 μM to 236.9 μM. [2] |
| In vivo | The maximum plasma concentration and half-life of MC3138 are approximately 230 μM and 5.059 hours, respectively. GOT activity was significantly reduced in PDX xenograft tumor mouse models treated with MC3138 (100-200 μM). [2] |
| Alias | MC 3138 |
| Molecular Weight | 435.47 |
| Formula | C25H25NO6 |
| Cas No. | 1844889-12-8 |
| Smiles | O=C(OCC)C1=CN(C=C(C(=O)OCC)C1C=2C=CC=C(OC)C2)C(=O)C=3C=CC=CC3 |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 160 mg/mL (367.42 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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