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MIV-247

🥰Excellent
TargetMol
Catalog No. T12051Cas No. 1352817-76-5

MIV-247 is a selective and potent inhibitor of cathepsin S (Kis 2.1, 4.2, and 7.5 nM for human, mouse, and wild monkey cathepsin S, respectively), which attenuates mechanical anomalies in preclinical models of neuropathic pain, and can be used to study cardiac muscle injury.

MIV-247

MIV-247

🥰Excellent
TargetMol
Purity: 99.31%
Catalog No. T12051Cas No. 1352817-76-5
MIV-247 is a selective and potent inhibitor of cathepsin S (Kis 2.1, 4.2, and 7.5 nM for human, mouse, and wild monkey cathepsin S, respectively), which attenuates mechanical anomalies in preclinical models of neuropathic pain, and can be used to study cardiac muscle injury.
Pack SizePriceAvailabilityQuantity
1 mg$1,370In Stock
2 mg$1,850In Stock
5 mg$2,750In Stock
10 mg$3,680In Stock
25 mg$5,490In Stock
50 mg$7,430In Stock
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Purity:99.31%
ee:100%
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Product Introduction

Bioactivity
Description
MIV-247 is a selective and potent inhibitor of cathepsin S (Kis 2.1, 4.2, and 7.5 nM for human, mouse, and wild monkey cathepsin S, respectively), which attenuates mechanical anomalies in preclinical models of neuropathic pain, and can be used to study cardiac muscle injury.
Targets&IC50
Cathepsin S (cynomolgus monkey):7.5 nM, Cathepsin S (human):2.1 nM, Cathepsin S (mouse):4.2 nM
In vivo
To assess the potential neurobehavioral side effects of MIV-247, oral administration of MIV-247 (100-200 μmol/kg) resulted in a dose-dependent reduction of mechanical allodynia, with up to approximately 50% reversal observed after single or twice-daily dosing for 5 days. No behavioral deficits were observed with any dose of MIV-247 tested[1].
Chemical Properties
Molecular Weight391.39
FormulaC17H24F3N3O4
Cas No.1352817-76-5
SmilesN(C([C@H](CC1(F)CCCC1)NC(C(C)(F)F)=O)=O)C2(C(C(N)=O)=O)CCC2
Relative Density.1.32 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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