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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | MK2-IN-5, a pseudosubstrate of Mk2 with an inhibition constant (K_i) of 8 μM, selectively targets the protein interaction domain of the MAPK pathway and inhibits the phosphorylation of HSP25 and HSP27 [1] [2] [3]. |
In vitro | MK2-IN-5 at concentrations of 5-10 nM for 2 hours inhibits the expression of connective tissue growth factor and type I collagen induced by TGF-b1 in human scar keloid fibroblasts [3]. |
In vivo | MK2-IN-5 (2 mg/kg, intraperitoneal injection, single dose) reduces HSP25 phosphorylation in ventilator-induced lung injury models [2]. |
Alias | Hsp25 kinase inhibitor, Mk2 pseudosubstrate |
Molecular Weight | 1396.68 |
Formula | C61H113N21O16 |
Cas No. | 474713-20-7 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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