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MK2-IN-5
Catalog No. T81783Cas No. 474713-20-7
Alias Mk2 pseudosubstrate, Hsp25 kinase inhibitor
MK2-IN-5, a pseudosubstrate of Mk2 with an inhibition constant (K_i) of 8 μM, selectively targets the protein interaction domain of the MAPK pathway and inhibits the phosphorylation of HSP25 and HSP27 [1] [2] [3].
MK2-IN-5
Catalog No. T81783Alias Mk2 pseudosubstrate, Hsp25 kinase inhibitorCas No. 474713-20-7
MK2-IN-5, a pseudosubstrate of Mk2 with an inhibition constant (K_i) of 8 μM, selectively targets the protein interaction domain of the MAPK pathway and inhibits the phosphorylation of HSP25 and HSP27 [1] [2] [3].
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Product Introduction
Bioactivity
Chemical Properties
| Description | MK2-IN-5, a pseudosubstrate of Mk2 with an inhibition constant (K_i) of 8 μM, selectively targets the protein interaction domain of the MAPK pathway and inhibits the phosphorylation of HSP25 and HSP27 [1] [2] [3]. |
| In vitro | MK2-IN-5 at concentrations of 5-10 nM for 2 hours inhibits the expression of connective tissue growth factor and type I collagen induced by TGF-b1 in human scar keloid fibroblasts [3]. |
| In vivo | MK2-IN-5 (2 mg/kg, intraperitoneal injection, single dose) reduces HSP25 phosphorylation in ventilator-induced lung injury models [2]. |
| Alias | Mk2 pseudosubstrate, Hsp25 kinase inhibitor |
| Molecular Weight | 1396.68 |
| Formula | C61H113N21O16 |
| Cas No. | 474713-20-7 |
Storage & Solubility Information
| Storage | keep away from moisture | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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