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ML-180 (SR1848) is a potent inverse agonist of the orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) with an IC50 of 3.7 μM.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 28 € | In Stock | |
2 mg | 41 € | In Stock | |
5 mg | 66 € | In Stock | |
10 mg | 110 € | In Stock | |
25 mg | 207 € | In Stock | |
50 mg | 362 € | In Stock | |
100 mg | 549 € | In Stock | |
1 mL x 10 mM (in DMSO) | 74 € | In Stock |
Description | ML-180 (SR1848) is a potent inverse agonist of the orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) with an IC50 of 3.7 μM. |
Targets&IC50 | LRH1:3.7 µM (IC50) |
In vitro | ML-180 (0.5-5 μM; 24 hours) shows a significant inhibition of cyclin-D1 and cyclin-E1 expression in hepatic cells, but has little effect on repression in SK-OV-3 cells[2]. ML-180 (5 μM; 24 hours) leads to a rapid decrease of LRH-1 expression and efficiently represses endogenous LRH-1 signaling[2]. |
In vivo | ML-180 has a statistically significant decrease of both LRH-1 and SHP mRNA in adrenal glands and pancreatic tissue[2]. |
Alias | SR1848 |
Molecular Weight | 388.89 |
Formula | C20H25ClN4O2 |
Cas No. | 863588-32-3 |
Smiles | Clc1cccc(c1)N1CCN(CC1)c1cc(=O)n(C2CCCCC2)c(=O)[nH]1 |
Relative Density. | 1.312 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 11 mg/mL (28.28 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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