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MMAF intermediate 1
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Catalog No. T89657Cas No. 161485-82-1
MMAFintermediate 1 serves as a precursor in the synthesis of MMAF (Monomethylauristatin F), an effective inhibitor of tubulin polymerization. MMAF is a cytotoxic component commonly used in antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. This compound plays a crucial role in the production of classic ADC cytotoxins.
MMAF intermediate 1
😃Good
Catalog No. T89657Cas No. 161485-82-1
MMAFintermediate 1 serves as a precursor in the synthesis of MMAF (Monomethylauristatin F), an effective inhibitor of tubulin polymerization. MMAF is a cytotoxic component commonly used in antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. This compound plays a crucial role in the production of classic ADC cytotoxins.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | MMAFintermediate 1 serves as a precursor in the synthesis of MMAF (Monomethylauristatin F), an effective inhibitor of tubulin polymerization. MMAF is a cytotoxic component commonly used in antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. This compound plays a crucial role in the production of classic ADC cytotoxins. |
| Molecular Weight | 448.55 |
| Formula | C24H36N2O6 |
| Cas No. | 161485-82-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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